JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB237697

Anti-TXNDC5 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal TXNDC5 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TXNDC5 aa 1-350.

View Alternative Names

TLP46, UNQ364/PRO700, TXNDC5, Thioredoxin domain-containing protein 5, Endoplasmic reticulum resident protein 46, Thioredoxin-like protein p46, ER protein 46, ERp46

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNDC5 antibody (AB237697)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNDC5 antibody (AB237697)

Paraffin-embedded human gastric cancer tissue stained for TXNDC5 with ab237697 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNDC5 antibody (AB237697)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNDC5 antibody (AB237697)

Paraffin-embedded human colon cancer tissue stained for TXNDC5 with ab237697 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-TXNDC5 antibody (AB237697)
  • WB

Supplier Data

Western blot - Anti-TXNDC5 antibody (AB237697)

All lanes:

Western blot - Anti-TXNDC5 antibody (ab237697) at 1/1000 dilution

Lane 1:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Lane 2:

COLO 320 (human colorectal adenocarcinoma cell line) whole cell lysate

Lane 3:

Mouse stomach tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TXNDC5 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q8NBS9

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TXNDC5 also known as Thioredoxin Domain-Containing Protein 5 is an endoplasmic reticulum-resident protein with a molecular mass of approximately 48 kDa. This protein functions as a disulfide isomerase assisting in the formation and rearrangement of disulfide bonds in newly synthesized proteins. Researchers note its high expression in tissues such as the liver lung and heart where protein folding demands are significant. Due to its involvement in protein folding TXNDC5 maintains cellular homeostasis and assists in proper protein assembly.
Biological function summary

TXNDC5 contributes to the oxidative folding of proteins within the endoplasmic reticulum. The protein does not act alone but as part of a larger complex involving other chaperones and foldases that together ensure protein quality control. TXNDC5 interfaces with the redox system impacting the oxidative environment necessary for correct protein folding. By contributing to this complex system TXNDC5 helps prevent the accumulation of misfolded proteins and maintains the integrity of cellular function.

Pathways

TXNDC5 plays a role in the protein folding pathway which is vital to maintaining cellular stability. In addition its involvement in the response to unfolded protein responses signifies its importance in stress-related pathways. TXNDC5 often interacts with other proteins such as PDI (Protein Disulfide Isomerase) and Calreticulin which are also important in protein folding and cellular stress responses. These pathways are essential for adapting to changes in protein synthesis demands and mitigating the effects of cellular stress.

TXNDC5 has associations with conditions such as rheumatoid arthritis and certain cancers. Aberrant expression levels of TXNDC5 correlate with increased inflammatory responses in rheumatoid arthritis indicating its role in disease progression. In cancer overexpression of this protein has been observed suggesting a potential role in tumor growth and survival. Additionally TXNDC5 interacts with proteins like Hsp70 (Heat Shock Protein 70) which also plays a role in these disorders by assisting in protein folding under stress conditions thereby potentially influencing disease outcomes.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.
See full target information TXNDC5
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Translational cancer research 13:81-101 PubMed38410208

2024

Validation of the interaction between PRDX4 and TXNDC5 in gastric cancer and the significance of the gene in gastric cancer based on a data mining analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Zhang,Kai Wu,Yanhong Hou,Xianghui Li

The Journal of biological chemistry 299:104982 PubMed37390992

2023

Persistent ER stress causes GPI anchor deficit to convert a GPI-anchored prion protein into pro-PrP via the ATF6-miR449c-5p-PIGV axis.

Applications

Unspecified application

Species

Unspecified reactive species

JingFeng Li,SaSa Li,ShuPei Yu,Jie Yang,JingRu Ke,Huan Li,Heng Chen,MingJian Lu,Man-Sun Sy,ZhenXing Gao,Chaoyang Li
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB227623

Anti-TXNDC5 antibody

Western blot - Anti-TXNDC5 antibody (AB227623)

  • 0
  • 0
Primary Antibodies

AB13820

Anti-TXNDC5 antibody

Immunocytochemistry/ Immunofluorescence - Anti-TXNDC5 antibody (AB13820)

  • 4
  • 1
Primary Antibodies

AB10292

Anti-TXNDC5 antibody

Western blot - Anti-TXNDC5 antibody (AB10292)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB172964

Anti-IDH1 antibody [EPR12296]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IDH1 antibody [EPR12296] (AB172964)

  • 5
  • 2
Primary Antibodies

AB182858

Anti-Bcl-2 antibody [EPR17509]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bcl-2 antibody [EPR17509] (AB182858)

  • 5
  • 13
Primary Antibodies

AB45179

Anti-Chromogranin A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Chromogranin A antibody (AB45179)

  • 5
  • 9
Primary Antibodies

AB52894

Anti-EGFR antibody [EP38Y]

BOND RX™ Validated|KO Validated|RabMAb|Lab Essentials|20ul selling size|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFR antibody [EP38Y] (AB52894)

  • 5
  • 24

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com