AB128249

Anti-Tyrosine Hydroxylase antibody

Name: Anti-Tyrosine Hydroxylase antibody (ab128249) | Abcam
Brand: Abcam Limited
SKU: AB128249
Price: 535 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal Tyrosine Hydroxylase antibody. Suitable for ELISA, WB and reacts with Drosophila melanogaster samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Drosophila melanogaster ple.

View Alternative Names

TH, CG10118, ple, Tyrosine 3-monooxygenase, Protein Pale, Tyrosine 3-hydroxylase

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Drosophila melanogaster

Applications

WB, ELISA

applications

Immunogen

Synthetic Peptide within Drosophila melanogaster ple. The exact immunogen used to generate this antibody is proprietary information.

P18459

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Drosophila melanogaster": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tyrosine hydroxylase also known as TH is an enzyme that catalyzes the conversion of L-tyrosine to L-DOPA. It weighs approximately 60 kDa. You can find this enzyme expressed mainly in the brain adrenal glands and some peripheral tissues. Commonly studied antibodies include anti-tyrosine hydroxylase or anti-TH. It plays a significant role in the catecholamine biosynthesis pathway serving as the rate-limiting step in dopamine synthesis.

Biological function summary

Tyrosine hydroxylase is essential for synthesizing catecholamines including dopamine norepinephrine and epinephrine. This enzyme associates with other components in the catecholamine biosynthetic pathway. It functions as part of a larger complex within certain cells where its action determines levels of important neurotransmitters. These neurotransmitters help regulate numerous central and peripheral nervous system activities.

Pathways

Tyrosine hydroxylase acts as a critical component in both the dopaminergic and adrenergic pathways. In the dopaminergic pathway tyrosine hydroxylase facilitates dopamine production influencing various physiological processes. The enzyme also correlates with ardrd protein in these pathways allowing fine-tuned control of neurotransmitter synthesis. Proteins related to tyrosine hydroxylase in these pathways include aromatic L-amino acid decarboxylase which further processes L-DOPA into dopamine.

Tyrosine hydroxylase has connections with neurodegenerative diseases like Parkinson's disease and conditions such as dystonia. Dysfunctional expression or activity of this enzyme can lead to dopamine deficiency contributing to the motor symptoms in Parkinson's disease. In dystonia alterations in tyrosine hydroxylase activity affect neurotransmitter balance influencing muscle coordination. The relationship with ardrd protein highlights tyrosine hydroxylase's role in maintaining neural health and it highlights potential areas for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays an important role in the physiology of adrenergic neurons.

See full target information ple

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Autophagy 21:447-459 PubMed39342484

2024

Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis in and Vici syndrome patients.

Applications

Unspecified application

Species

Unspecified reactive species

Celine Deneubourg,Hormos Salimi Dafsari,Simon Lowe,Aitana Martinez-Cotrina,David Mazaud,Seo Hyun Park,Virginia Vergani,Amanda Almacellas Barbanoj,Reza Maroofian,Luisa Averdunk,Ehsan Ghayoor-Karimiani,Sandeep Jayawant,Cyril Mignot,Boris Keren,Renate Peters,Arveen Kamath,Lauren Mattas,Sumit Verma,Arpana Silwal,Felix Distelmaier,Henry Houlden,Gabriele Lignani,Adam Antebi,James Jepson,Heinz Jungbluth,Manolis Fanto

Vavilovskii zhurnal genetiki i selektsii 27:250-263 PubMed37293442

2023

LIM-kinase 1 effects on memory abilities and male courtship song in Drosophila depend on the neuronal type.

Applications

Unspecified application

Species

Unspecified reactive species

A V Zhuravlev,E S Zalomaeva,E S Egozova,V V Sokurova,E A Nikitina,E V Savvateeva-Popova

International journal of molecular sciences 23: PubMed36293213

2022

Mutation in Affects Phenoxazinone Synthase Catalytic Site and Impairs Long-Term Memory.

Applications

Unspecified application

Species

Unspecified reactive species

Aleksandr V Zhuravlev,Polina N Ivanova,Ksenia A Makaveeva,Gennadii A Zakharov,Ekaterina A Nikitina,Elena V Savvateeva-Popova

Pest management science 78:3540-3550 PubMed35587569

2022

MicroRNAs miR-14 and miR-2766 regulate tyrosine hydroxylase to control larval-pupal metamorphosis in Helicoverpa armigera.

Applications

Unspecified application

Species

Unspecified reactive species

Zhong-Jian Shen,Fang Zhu,Yan-Jun Liu,Zhen Li,Timothy W Moural,Xiao-Ming Liu,Xiaoxia Liu

International journal of molecular sciences 19: PubMed29914172

2018

Big Lessons from Tiny Flies: as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems.

Applications

Unspecified application

Species

Unspecified reactive species

Ameya Sanjay Kasture,Thomas Hummel,Sonja Sucic,Michael Freissmuth

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Tyrosine Hydroxylase antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise