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AB150659

Anti-Tyrosine Hydroxylase antibody [TOH A1.1] - Neuronal Marker

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(6 Publications)

Mouse Monoclonal Tyrosine Hydroxylase antibody. Suitable for EM, ICC/IF, IHC-Fr and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Native Full Length Protein corresponding to Rat TH.

View Alternative Names

Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH, Th

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

TOH A1.1

Isotype

IgG1

Carrier free

No

Reacts with

Rat

Applications

EM, IHC-Fr, ICC/IF

applications

Immunogen

Native Full Length Protein corresponding to Rat TH.

P04177

Specificity

The antibody recognizes the full length TOH

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Alternative Products

Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "EM" : {"fullname" : "Electron Microscopy", "shortname":"EM"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "EM-species-checked": "guaranteed", "EM-species-dilution-info": "", "EM-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Product details

ab150659 reacts with tyrosine hydroxylase immunoreactive sites in the known catecholaminergic neurons and and fibre systems of rat brain. It recognizes best the configuration of tyrosine hydroxylase in fixed tissues.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Lyophilized protein G purified in PBS pH7.4
Storage buffer
Constituents: 99% Water
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tyrosine hydroxylase also known as TH is an enzyme that catalyzes the conversion of L-tyrosine to L-DOPA. It weighs approximately 60 kDa. You can find this enzyme expressed mainly in the brain adrenal glands and some peripheral tissues. Commonly studied antibodies include anti-tyrosine hydroxylase or anti-TH. It plays a significant role in the catecholamine biosynthesis pathway serving as the rate-limiting step in dopamine synthesis.
Biological function summary

Tyrosine hydroxylase is essential for synthesizing catecholamines including dopamine norepinephrine and epinephrine. This enzyme associates with other components in the catecholamine biosynthetic pathway. It functions as part of a larger complex within certain cells where its action determines levels of important neurotransmitters. These neurotransmitters help regulate numerous central and peripheral nervous system activities.

Pathways

Tyrosine hydroxylase acts as a critical component in both the dopaminergic and adrenergic pathways. In the dopaminergic pathway tyrosine hydroxylase facilitates dopamine production influencing various physiological processes. The enzyme also correlates with ardrd protein in these pathways allowing fine-tuned control of neurotransmitter synthesis. Proteins related to tyrosine hydroxylase in these pathways include aromatic L-amino acid decarboxylase which further processes L-DOPA into dopamine.

Tyrosine hydroxylase has connections with neurodegenerative diseases like Parkinson's disease and conditions such as dystonia. Dysfunctional expression or activity of this enzyme can lead to dopamine deficiency contributing to the motor symptoms in Parkinson's disease. In dystonia alterations in tyrosine hydroxylase activity affect neurotransmitter balance influencing muscle coordination. The relationship with ardrd protein highlights tyrosine hydroxylase's role in maintaining neural health and it highlights potential areas for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan but with lower specificity (PubMed : 10933781, PubMed : 11922614). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity).
See full target information TH
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in neuroscience 17:1323727 PubMed38188034

2024

Scalp electroacupuncture targeting the VTA neurons to relieve negative emotions and promote the alleviation of chronic pain.

Applications

Unspecified application

Species

Unspecified reactive species

Yanan Yang,Xiali Wei,Jun Tian,Ye Zhu,Shaohui Jia,Qing Shu

Annals of translational medicine 10:1314 PubMed36660708

2023

Right vagus nerve stimulation improves motor behavior by exerting neuroprotective effects in Parkinson's disease rats.

Applications

Unspecified application

Species

Unspecified reactive species

Chaofan Wang,Tong Su,Lifei Xiao,Yangyang Wang,Xianhao Huo,Wenchao Li,Jiangwei Ding,Tao Sun

Brain research bulletin 170:187-198 PubMed33610724

2021

Altered expression of voltage gated sodium channel Nav1.1 is involved in motor ability in MPTP-treated mice.

Applications

Unspecified application

Species

Unspecified reactive species

Weitang Liu,Wenwen Lao,Renxing Zhang,Hongyan Zhu

Reproductive biology and endocrinology : RB&E 17:53 PubMed31292004

2019

Comparative study of environmental pollutants bisphenol A and bisphenol S on sexual differentiation of anteroventral periventricular nucleus and spermatogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Naham John,Humaira Rehman,Suhail Razak,Mehwish David,Waheed Ullah,Tayyaba Afsar,Ali Almajwal,Iftikhar Alam,Sarwat Jahan

The Journal of neuroscience : the official journal of the Society for Neuroscience 6:3640-54 PubMed2432203

1986

Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS.

Applications

ICC/IF

Species

Rat

T Melander,T Hökfelt,A Rökaeus,A C Cuello,W H Oertel,A Verhofstad,M Goldstein

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 34:817-21 PubMed2871071

1986

A monoclonal antibody against tyrosine hydroxylase: application in light and electron microscopy.

Applications

IHC-P, ICC/IF

Species

Rat, Rat

F M Semenenko,A C Cuello,M Goldstein,K Y Lee,E Sidebottom
View all publications
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