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AB122106

Anti-TYSND1 antibody

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(1 Publication)

Rabbit Polyclonal TYSND1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TYSND1 aa 400-500.

View Alternative Names

Peroxisomal leader peptide-processing protease, Trypsin domain-containing protein 1, TYSND1

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TYSND1 antibody (AB122106)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TYSND1 antibody (AB122106)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labeling TYSND1 with ab122106 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TYSND1 antibody (AB122106)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TYSND1 antibody (AB122106)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labeling TYSND1 with ab122106 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TYSND1 antibody (AB122106)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TYSND1 antibody (AB122106)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human duodenum tissue labeling TYSND1 with ab122106 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TYSND1 antibody (AB122106)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TYSND1 antibody (AB122106)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin tissue labeling TYSND1 with ab122106 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Western blot - Anti-TYSND1 antibody (AB122106)
  • WB

Supplier Data

Western blot - Anti-TYSND1 antibody (AB122106)

All lanes:

Western blot - Anti-TYSND1 antibody (ab122106) at 0.4 µg/mL

Lane 1:

RT4 (human urinary bladder cancer cell line) whole cell lysate

Lane 2:

U-251 MG (formally U-373 MG) (human brain glioma cell line) whole cell lysate

Predicted band size: 59 kDa

false

Western blot - Anti-TYSND1 antibody (AB122106)
  • WB

Supplier Data

Western blot - Anti-TYSND1 antibody (AB122106)

All lanes:

Western blot - Anti-TYSND1 antibody (ab122106) at 0.4 µg/mL

Lane 1:

NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate

Lane 2:

NBT-II (rat urinary bladder tumor cell line) whole cell lysate

Predicted band size: 59 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Rat

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TYSND1 aa 400-500. The exact immunogen used to generate this antibody is proprietary information.

Q2T9J0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TYSND1 also known as Trypsin-5 is a serine protease enzyme with a molecular mass of approximately 46 kDa. It plays an important role in catalyzing the cleavage of peptide bonds in various substrate proteins. TYSND1 primarily localizes in the peroxisomes and mitochondria where it is highly expressed. In particular it is found in tissues with high metabolic activities like the liver and kidney suggesting it has functions in energy metabolism and cellular detoxification processes.
Biological function summary

TYSND1 contributes to the maintenance of protein homeostasis by participating in the processing of proteins that are imported into peroxisomes. It forms part of a larger complex involved in the maturation and processing of peroxisomal matrix proteins. This process ensures that imported proteins achieve their proper functional forms which is important for peroxisome function. Additionally TYSND1 aids in the cleavage of the enzyme PTS1 which signals protein import into peroxisomes therefore influencing peroxisomal protein composition and activity.

Pathways

TYSND1 plays important roles in the peroxisomal protein import pathway and the fatty acid β-oxidation pathway. In the import pathway TYSND1 works with other proteins such as PEX11 and PEX13 to facilitate the correct targeting and processing of enzymes that execute peroxisomal functions. In the fatty acid β-oxidation pathway TYSND1 acts indirectly by ensuring the availability and proper configuration of enzymes that catalyze the breakdown of fatty acids which is an important energy production process.

Dysregulation of TYSND1 activity has links to disorders like peroxisome biogenesis disorders and fatty liver disease. Peroxisome biogenesis disorders result from impaired import of necessary enzymes into peroxisomes potentially linked to dysfunctional TYSND1 activity. Additionally alterations in TYSND1 expression are associated with metabolic conditions such as fatty liver disease where it interacts with proteins like PPARα that regulate lipid metabolism. Understanding TYSND1 functions and regulation may provide insights into therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
See full target information TYSND1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Human molecular genetics 31:1970-1978 PubMed34999892

2022

Mutations in the ribosome biogenesis factor gene LTV1 are linked to LIPHAK syndrome, a novel poikiloderma-like disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Hoon Han,Gavin Ryan,Alyson Guy,Lu Liu,Mathieu Quinodoz,Ingrid Helbling,Joey E Lai-Cheong,Julian Barwell,Marc Folcher,John A McGrath,Celia Moss,Carlo Rivolta
View all publications
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Product promise

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