Anti-Uba6 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Uba6 also known as ubiquitin-like modifier activating enzyme 6 is an E1-like ubiquitin-activating enzyme. It has an approximate mass of around 120 kDa. This enzyme facilitates the activation of ubiquitin and similar proteins by catalyzing the formation of a ubiquitin-adenylate intermediate. Uba6 is expressed in a wide range of human tissues with higher levels observed in the brain heart and skeletal muscle. Its expression suggests a need for its activity in diverse biological processes across different tissue types.

Biological function summary

Uba6 modifies proteins by attaching ubiquitin moieties which tags them for various fates including degradation or location changes. Uba6 functions as a part of the ubiquitin-proteasome system (UPS) a critical protein degradation and quality control pathway. In this system Uba6 collaborates with E2 conjugating enzymes such as Ube2z which transfer ubiquitin from Uba6 to substrate proteins. This involvement emphasizes its role in protein homeostasis and cellular stress responses by controlling protein stability.

Pathways

Uba6 takes part in the maintenance of protein homeostasis and also influences the NEDD8 modification pathway. The UPS pathway integrates Uba6 with processes involving protein turnover and stress responses maintaining cellular oxidative stress levels. In the NEDD8 pathway Uba6 interacts with proteins like UBE2D which influence protein degradation scenarios that differ from those managed by the classic ubiquitin system. These pathways highlight the diverse regulatory roles Uba6 holds in managing intracellular protein dynamics.

Associated diseases and disorders

Uba6 plays a role in neurodegenerative diseases and some cancers. In Alzheimer's disease Uba6 affects the accumulation of misfolded proteins connecting its action to the degradation pathways that include related ubiquitination enzymes. It also shows relevance to tumor progression in cancers where aberrations in ubiquitin-mediated pathways play a part in unregulated cell growth. The functions of Uba6 in these conditions link it with disorders of protein homeostasis where proteins like UBE2Z are involved.