Anti-UBAP1 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UBAP1 also known as Ubiquitin Associated Protein 1 functions in the endosomal sorting complex required for transport (ESCRT) pathway. It has a molecular mass of approximately 55 kDa. This protein binds ubiquitinated cargo as part of its role in sorting and trafficking cellular components for degradation. UBAP1 primarily expresses in the brain liver and lung tissues where it plays an important role in maintaining cellular homeostasis through the ESCRT-I complex.

Biological function summary

UBAP1 supports the regulation of protein degradation and recycling within the cell. As part of the ESCRT-I complex UBAP1 interacts with other ESCRT machinery to facilitate the formation of multivesicular bodies (MVBs). These MVBs transport ubiquitinated proteins to lysosomes for degradation. UBAP1 works closely with proteins such as TSG101 and VPS28 in this capacity ensuring efficient operational function of cellular waste management.

Pathways

Several cell processes rely on UBAP1's integration into the ESCRT system including vesicular trafficking and receptor degradation. Within the ubiquitin-proteasome system UBAP1 functions alongside proteins like VPS37B to regulate the sorting of ubiquitinated receptors into internal vesicles of the MVBs. Influencing the endosomal-lysosomal pathway UBAP1 ensures proper disposal of cellular components an important process for maintaining cell health.

UBAP1 mutations or dysfunctions have connections to neurodegenerative conditions and certain types of cancers. In particular its altered function has associations with frontotemporal dementia a disorder that affects brain functioning by impairing protein homeostasis. UBAP1 mutations link to ubiquilin 2 (UBQLN2) activity as both are involved in maintaining neural cellular health. Additionally a deficiency in UBAP1 function may contribute to the progression of hepatocellular carcinoma due to the disruption of normal degradation pathways and increased cellular stress.