AB121693

Anti-UBAP2 antibody

Name: Anti-UBAP2 antibody (ab121693) | Abcam
Brand: Abcam Limited
SKU: AB121693
Price: 630 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal UBAP2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UBAP2 aa 400-550.

View Alternative Names

KIAA1491, UBAP2, Ubiquitin-associated protein 2, UBAP-2, RNA polymerase II degradation factor UBAP2

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Immunohistochemical analysis of human skin tissue labeling UBAP2 with ab121693 at a 1/50 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Immunohistochemical analysis of human testis cancer tissue labeling UBAP2 with ab121693 at a 1/50 dilution.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Immunohistochemical staining of paraffin embedded Human tonsil tissue, using 1/150 ab121693,

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Immunohistochemical analysis of human testis tissue labeling UBAP2 with ab121693 at a 1/50 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Immunohistochemical analysis of human placenta tissue labeling UBAP2 with ab121693 at a 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human UBAP2 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.

Q5T6F2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p>Use buffer at pH 6 for antigen retrieval.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UBAP2 also known as Ubiquitin-Associated Protein 2 plays a role in cellular processes by interacting with ubiquitin-related pathways. It has a mass of approximately 115 kDa. This protein functions mainly in the cytoplasm but is also present in the nucleus in certain cell types. UBAP2 expression occurs in a wide range of tissues with higher levels observed in immune cells such as lymphocytes.

Biological function summary

UBAP2 interacts with components of the endosomal sorting complex required for transport (ESCRT) machinery. This interaction suggests a role in vesicle trafficking and membrane dynamics. UBAP2 has not been reported as part of a complex but might work closely with other ubiquitin-interacting proteins to regulate endocytic processes. It may assist in sorting endocytosed proteins for degradation or recycling.

Pathways

UBAP2 takes part in ubiquitin-mediated processes and is linked to the intracellular trafficking pathway. Its interaction with the ESCRT machinery indicates participation in endosomal and lysosomal pathways. Related proteins include ubiquitin and TSG101 which are involved in coordinating the sorting and transport of proteins through the endosomal system.

Researchers investigate UBAP2 for its potential link to neurodegenerative diseases such as Alzheimer's disease and certain cancers. Studies propose that altered ubiquitin pathways may contribute to these conditions implicating proteins like TSG101. Alterations in UBAP2 function might therefore disrupt normal cellular processes contributing to disease progression and pathology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed : 35633597). May promote the degradation of ANXA2 (PubMed : 27121050).

See full target information UBAP2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Discover oncology 15:246 PubMed38926181

2024

Comprehensive bioinformatics analysis of integrator complex subunits: expression patterns, immune infiltration, and prognostic signature, validated through experimental approaches in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yifei Xu,Wenlian Liao,Ting Wang,Liwei Zhang,Hui Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-UBAP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2 antibody (AB121693)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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