Anti-UBE2E2 antibody [EPR13003(B)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

UBE2E2 also known as UBC2 or UBCH8 functions as an E2 ubiquitin-conjugating enzyme involved in the ubiquitination pathway. It has a mass of approximately 25 kDa. This enzyme catalyzes the transfer of ubiquitin from an E1 activating enzyme to a substrate protein marking it for degradation by the proteasome or other cellular processes like DNA repair or cell cycle regulation. UBE2E2 is expressed in various tissues with significant levels found in the liver and pancreas indicating its broad functional importance within the cell.

Biological function summary

UBE2E2 plays a significant role in protein homeostasis and cellular regulation. It often acts as part of a larger ubiquitin-proteasome system (UPS) complex where it partners with specific E3 ligases to target proteins for ubiquitination. Through these interactions it influences vital processes such as cell growth apoptosis and response to stress maintaining the balance of protein synthesis and degradation in cells. Its action ensures cells adapt to changes in the environment by regulating protein turnover.

Pathways

The ubiquitination activity of UBE2E2 is essential in the regulation of pathways like the cell cycle and DNA damage repair pathways. It interacts closely with proteins such as c-Cbl and Mdm2 linking to pathways that manage cell proliferation and response to genotoxic stress. By facilitating the degradation of key regulatory proteins UBE2E2 helps to control cell cycle progression and repair mechanisms thereby maintaining genomic stability.

Associated diseases and disorders

Altered UBE2E2 activity associates with conditions like type 2 diabetes and certain cancers. UBE2E2's role in metabolic regulation and maintenance of cellular protein homeostasis connects it with insulin signaling pathways. For instance a dysfunctional UBE2E2 activity can disrupt interactions with insulin receptor substrate 1 (IRS1) leading to impaired glucose uptake and metabolism. In the context of cancer UBE2E2's dysregulation can affect tumor suppressor proteins further contributing to uncontrolled cell growth and survival.