Anti-UBE3D antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

UBE3D takes part in cellular protein homeostasis and regulation. It functions as an E3 ligase that tags proteins with ubiquitin an activity that usually signals these proteins for breakdown. Although not part of fully characterized complexes UBE3D likely interacts with multiple cofactors that assist in substrate recognition and ubiquitin transfer. This activity helps maintain cellular protein quality and modulate signaling pathways by controlling the abundance of key regulatory proteins.

Pathways

UBE3D is essential in the ubiquitin-proteasome system a pathway important for controlling protein turnover and degradation. This pathway ensures that damaged or misfolded proteins do not accumulate in cells thereby maintaining cellular health. UBE3D is also connected to the p53 signaling pathway through its role in regulating proteins that interact with p53 an important protein involved in cell cycle regulation and apoptosis. UBE3D therefore contributes to cell cycle control and stress responses affecting how cells react to various stimuli.