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AB191691

Anti-UBIAD1 antibody - C-terminal

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(3 Publications)

Rabbit Polyclonal UBIAD1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human UBIAD1.

View Alternative Names

TERE1, UBIAD1, UbiA prenyltransferase domain-containing protein 1, Transitional epithelial response protein 1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBIAD1 antibody - C-terminal (AB191691)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBIAD1 antibody - C-terminal (AB191691)

Immunohistochemical staining of mouse liver tissue, labeling UBIAD1 using ab191691 at 20 μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBIAD1 antibody - C-terminal (AB191691)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBIAD1 antibody - C-terminal (AB191691)

Immunohistochemical analysis of paraffin-embedded mouse liver tissue, labeling UBIAD1 using ab191691 at 5 μg/mL.

Western blot - Anti-UBIAD1 antibody - C-terminal (AB191691)
  • WB

Supplier Data

Western blot - Anti-UBIAD1 antibody - C-terminal (AB191691)

All lanes:

Western blot - Anti-UBIAD1 antibody - C-terminal (ab191691) at 1 µg/mL

Lane 1:

mouse liver tissue lysate at 15 µg

Lane 2:

mouse liver tissue lysate at 15 µg with blocking peptide

Predicted band size: 37 kDa

Observed band size: 45 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human UBIAD1. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5Z9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UBIAD1 also known as UbiA prenyltransferase domain-containing protein 1 is a human gene encoding an enzyme with an important role in cellular processes. This enzyme has a mass of approximately 32 kDa and is expressed in various tissues including liver kidney and heart. UBIAD1 is involved in the synthesis of menaquinone-4 (MK-4) a form of vitamin K2 and it participates in cholesterol metabolism. Through its function this enzyme contributes to the production of coenzyme Q10 essential for mitochondrial energy production.
Biological function summary

UBIAD1 helps regulate lipid metabolism and cellular oxidative stress responses. The protein does not form a larger complex but functions independently to facilitate the biosynthesis of specific lipids. Its role in managing oxidative stress is particularly important as it can impact the production of reactive oxygen species within cells. By maintaining the balance of cellular lipids and redox states UBIAD1 supports overall cell health.

Pathways

UBIAD1 acts in both the mevalonate pathway and the vitamin K cycle. In the mevalonate pathway UBIAD1 contributes to the production of cholesterol and non-sterol isoprenoids. It works alongside related proteins such as HMG-CoA reductase a critical enzyme in cholesterol biosynthesis. UBIAD1 also plays a role in the vitamin K cycle which is important for activating clotting factors necessary for blood coagulation. This involvement highlights its participation in key metabolic and regulatory pathways.

Mutations in UBIAD1 can lead to Schnyder corneal dystrophy (SCD) a rare genetic disorder characterized by progressive opacification of the cornea. Research indicates that abnormal UBIAD1 function can disrupt cholesterol metabolism resulting in crystalline deposits in the cornea. Additionally UBIAD1 has connections to cardiovascular diseases due to its role in cholesterol regulation. Proteins such as apolipoprotein E (ApoE) may interact with UBIAD1 in the context of these disorders influencing lipid transport and metabolism.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10 (PubMed : 20953171, PubMed : 23374346). MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development (PubMed : 20953171). Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4 (PubMed : 20953171). Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme : coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system (PubMed : 23374346). Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (PubMed : 23374346).
See full target information UBIAD1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:7022 PubMed40016272

2025

Hepatic lipid metabolism is altered in Ubiad1 mice of both sexes.

Applications

Unspecified application

Species

Unspecified reactive species

Ryoko Higa,Shirin Pourteymour,Pratibha S Kolan,Simon N Dankel,Johan Fernø,Gunnar Mellgren,Calvin Pan,Marcus M Seldin,Aldons J Lusis,Christian A Drevon,Knut T Dalen,Frode A Norheim

Frontiers in cellular neuroscience 14:580206 PubMed33281557

2020

Olfactory Mucosa Mesenchymal Stem Cells Ameliorate Cerebral Ischemic/Reperfusion Injury Through Modulation of UBIAD1 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Jianyang Liu,Yan Huang,Jialin He,Yi Zhuo,Wei Chen,Lite Ge,Da Duan,Ming Lu,Zhiping Hu

Molecular medicine reports 16:6910-6915 PubMed28901410

2017

Depletion of ubiA prenyltransferase domain containing 1 expression promotes angiotensin II‑induced hypertrophic response in AC16 human myocardial cells via modulating the expression levels of coenzyme Q10 and endothelial nitric oxide synthase.

Applications

Unspecified application

Species

Unspecified reactive species

Bingju Yan,Yingxian Sun,Jun Wang
View all publications
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