Rabbit Polyclonal UBIAD1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human UBIAD1.
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Publications
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- Frontiers in cellular neuroscience 14:5802062020Olfactory Mucosa Mesenchymal Stem Cells Ameliorate Cerebral Ischemic/Reperfusion Injury Through Modulation of UBIAD1 Expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJianyang Liu et. al.PubMed 33281557
- Molecular medicine reports 16:6910-69152017Depletion of ubiA prenyltransferase domain containing 1 expression promotes angiotensin II‑induced hypertrophic response in AC16 human myocardial cells via modulating the expression levels of coenzyme Q10 and endothelial nitric oxide synthase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBingju Yan et. al.PubMed 28901410
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human UBIAD1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y5Z9
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Mouse | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1.00000-2.00000 µg/mL | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 5.00000-20.00000 µg/mL | Notes - |
Target data
Function
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.
Alternative names
UbiA prenyltransferase domain-containing protein 1, Transitional epithelial response protein 1, UBIAD1, TERE1
Recommended products
Rabbit Polyclonal UBIAD1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human UBIAD1.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human UBIAD1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y5Z9
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
UBIAD1 also known as UbiA prenyltransferase domain-containing protein 1 is a human gene encoding an enzyme with an important role in cellular processes. This enzyme has a mass of approximately 32 kDa and is expressed in various tissues including liver kidney and heart. UBIAD1 is involved in the synthesis of menaquinone-4 (MK-4) a form of vitamin K2 and it participates in cholesterol metabolism. Through its function this enzyme contributes to the production of coenzyme Q10 essential for mitochondrial energy production.
- Biological function summary
UBIAD1 helps regulate lipid metabolism and cellular oxidative stress responses. The protein does not form a larger complex but functions independently to facilitate the biosynthesis of specific lipids. Its role in managing oxidative stress is particularly important as it can impact the production of reactive oxygen species within cells. By maintaining the balance of cellular lipids and redox states UBIAD1 supports overall cell health.
- Pathways
UBIAD1 acts in both the mevalonate pathway and the vitamin K cycle. In the mevalonate pathway UBIAD1 contributes to the production of cholesterol and non-sterol isoprenoids. It works alongside related proteins such as HMG-CoA reductase a critical enzyme in cholesterol biosynthesis. UBIAD1 also plays a role in the vitamin K cycle which is important for activating clotting factors necessary for blood coagulation. This involvement highlights its participation in key metabolic and regulatory pathways.
- Associated diseases and disorders
Mutations in UBIAD1 can lead to Schnyder corneal dystrophy (SCD) a rare genetic disorder characterized by progressive opacification of the cornea. Research indicates that abnormal UBIAD1 function can disrupt cholesterol metabolism resulting in crystalline deposits in the cornea. Additionally UBIAD1 has connections to cardiovascular diseases due to its role in cholesterol regulation. Proteins such as apolipoprotein E (ApoE) may interact with UBIAD1 in the context of these disorders influencing lipid transport and metabolism.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-UBIAD1 antibody - C-terminal (ab191691)
All lanes: Western blot - Anti-UBIAD1 antibody - C-terminal (ab191691) at 1 µg/mL
All lanes: mouse liver tissue lysate at 15 µg
Developed using the ECL technique.
Predicted band size: 37 kDa
Observed band size: 45 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBIAD1 antibody - C-terminal (ab191691)
Immunohistochemical staining of mouse liver tissue, labeling UBIAD1 using ab191691 at 20 μg/mL.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBIAD1 antibody - C-terminal (ab191691)
Immunohistochemical analysis of paraffin-embedded mouse liver tissue, labeling UBIAD1 using ab191691 at 5 μg/mL.
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