Rabbit Polyclonal UCP2 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Mouse Ucp2 aa 200-300 conjugated to Keyhole Limpet Haemocyanin.
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- Frontiers in cell and developmental biology 10:8917312022Identification of UCP1 and UCP2 as Potential Prognostic Markers in Breast Cancer: A Study Based on Immunohistochemical Analysis and Bioinformatics.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXin Yu,Manman Shi,Qi Wu,Wen Wei,Shengrong Sun,Shan ZhuPubMed 35874806
- Molecular medicine reports 25:2021Phytochemical‑rich herbal formula ATG‑125 protects against sucrose‑induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChing-Chuan Yeh,Hsuan-Miao Liu,Ming-Chung Lee,Yann-Lii Leu,Wei-Han Chiang,Hen-Hong Chang,Tzung-Yan LeePubMed 34913071
- International journal of molecular sciences 22:2021Losartan Prevents Hepatic Steatosis and Macrophage Polarization by Inhibiting HIF-1α in a Murine Model of NAFLD.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCheng-Hui Wang,Hsuan-Miao Liu,Zi-Yu Chang,Tse-Hung Huang,Tzung-Yan LeePubMed 34360607
- Journal of neuroinflammation 17:222020Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFernando Bartolome et. al.PubMed 31937343
- Journal of cellular and molecular medicine 24:996-10092019Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin αVβ5 receptor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJianbin Bi,Jia Zhang,Yifan Ren,Zhaoqing Du,Teng Li,Tao Wang,Lin Zhang,Mengzhou Wang,Zheng Wu,Yi Lv,Rongqian WuPubMed 31701659
- Cell reports 28:2306-2316.e52019UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEsther Aguilar,Pauline Esteves,Tiphaine Sancerni,Véronique Lenoir,Thomas Aparicio,Frédéric Bouillaud,Renaud Dentin,Carina Prip-Buus,Daniel Ricquier,Claire Pecqueur,Sandra Guilmeau,Marie-Clotilde Alves-GuerraPubMed 31461648
- Scientific reports 9:116672019(Pro)renin receptor contributes to renal mitochondria dysfunction, apoptosis and fibrosis in diabetic mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCaixia Li,Luis C Matavelli,Safia Akhtar,Helmy M SiragyPubMed 31406124
- Redox biology 20:296-3062018Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJianbin Bi,Jia Zhang,Yifan Ren,Zhaoqing Du,Qingshan Li,Yue Wang,Shasha Wei,Lifei Yang,Jingyao Zhang,Chang Liu,Yi Lv,Rongqian WuPubMed 30388684
- Frontiers in molecular neuroscience 11:2672018Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJianmei Gao,Shuang Liu,Fan Xu,Yuangui Liu,Chun Lv,Yan Deng,Jingshan Shi,Qihai GongPubMed 30104959
- Medical science monitor : international medical jo 24:3702-37092018Low-Dose 4-Hydroxy-2-Nonenal (HNE) Reperfusion Therapy Displays Cardioprotective Effects in Mice After Myocardial Infarction That Are Abrogated by Genipin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing-Nan Wang et. al.PubMed 29858912
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Mouse Ucp2 aa 200-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P70406
Reactivity data
Select an application| IHC-P | |
|---|---|
| Mouse | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/100.00000 - 1/500.00000 | Notes (or 1/50 - 1/200 if using a fluorescent secondary antibody) |
Associated Products
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2 products for Alternative Product
Target data
Function
Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity). May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides (By similarity) (PubMed:11101840, PubMed:11756659, PubMed:12011051, PubMed:21785437, PubMed:25127353). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis (PubMed:26919426). Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537). Can unidirectionally transport anions including L-malate, L-aspartate, phosphate and chloride ions (By similarity). Does not mediate adaptive thermogenesis (PubMed:11101840).
Alternative names
Slc25a8, Ucp2, Dicarboxylate carrier UCP2, Mitochondrial uncoupling protein 2, Solute carrier family 25 member 8, UCPH, UCP 2
Recommended products
Rabbit Polyclonal UCP2 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Mouse Ucp2 aa 200-300 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Mouse Ucp2 aa 200-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P70406
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
UCP2 also known as Uncoupling Protein 2 is a mitochondrial protein that plays a role in regulating the production of heat by uncoupling oxidative phosphorylation from ATP synthesis. It has a molecular mass of approximately 33 kDa. UCP2 can be found in various tissues like the brain pancreas heart and adipose tissue. This protein facilitates the transport of protons across the inner mitochondrial membrane which dissipates the proton gradient leading to a reduction in ATP synthesis efficiency.
- Biological function summary
UCP2 influences energy balance and metabolism in cells. It is not part of a complex but it functions independently as a transporter within the mitochondrial membrane. UCP2 modulates reactive oxygen species (ROS) production impacting antioxidant defenses and influencing insulin secretion. Its role in decreasing ROS is particularly important for protecting cells from oxidative damage and helping in the maintenance of cellular homeostasis.
- Pathways
UCP2 is critical to thermogenesis and energy expenditure mechanisms. It is involved in the oxidative phosphorylation pathway affecting how cells produce energy. The protein is related to others in its family such as UCP1 and UCP3 which have similar functions but are expressed differently. UCP2 also intersects with pathways involving glucose metabolism where it influences insulin function and glucose uptake indirectly through its regulatory action.
- Associated diseases and disorders
UCP2 has links to obesity and diabetes. Its role in energy regulation and control of ROS offers insights into how imbalances can lead to metabolic syndromes. In obesity altered UCP2 expression may contribute to changes in energy expenditure and fat storage regulation. For diabetes UCP2 is closely connected to insulin signaling where its function impacts insulin secretion from pancreatic beta-cells. These connections underline the potential of UCP2 as a therapeutic target for metabolic diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UCP2 antibody (ab203244)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Mouse brain tissue labeling UCP2 with ab203244 at 1/400 dilution, followed by conjugation to the secondary antibody and DAB staining.
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