Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Product Insider Program
Be the first to know about our latest product launches - and unlock exclusive offers and discounts.
Rabbit Polyclonal UCP4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A27 aa 1-200.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.
Mitochondrial uncoupling protein 4, UCP 4, Solute carrier family 25 member 27, UNQ772/PRO1566, UCP4, SLC25A27
Rabbit Polyclonal UCP4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A27 aa 1-200.
Mitochondrial uncoupling protein 4, UCP 4, Solute carrier family 25 member 27, UNQ772/PRO1566, UCP4, SLC25A27
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Recombinant Fragment Protein within Human SLC25A27 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Database link O95847
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
UCP4 mediates heat production by uncoupling oxidative phosphorylation. UCP4 participates in reducing reactive oxygen species production within cells by regulating the mitochondrial respiration rate. It functions as part of a protein family consisting of other uncoupling proteins such as UCP1 UCP2 and UCP3. This family collectively contributes to the non-shivering thermogenesis process a mechanism essential for maintaining body temperature and metabolic efficiency.
The protein UCP4 also known as Uncoupling Protein 4 or SLC25A27 is part of the mitochondrial inner membrane and operates mechanically to dissipate the proton gradient. This action decreases the mitochondrial membrane potential. UCP4 has a molecular mass of approximately 36 kDa. This protein is highly expressed in brain tissue particularly within the central nervous system where it plays an important role in energy regulation.
UCP4 takes part in the regulation of energy metabolism and is involved in adaptive thermogenesis. Within these energy metabolism pathways UCP4 interacts with proteins involved in the control of cellular energy expenditure and homeostasis. It works in conjunction with UCP2 and UCP3 to regulate metabolic rates and energy balance influencing processes such as the glycolysis pathway to adapt energy production to the physiological needs of the organism.
UCP4 has associations with neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. It regulates mitochondrial dysfunction which is a characteristic feature of these disorders. In Alzheimer’s disease UCP4 may interact with proteins like amyloid precursor protein (APP) that play a role in disease pathology. Its dysregulation can lead to impaired mitochondrial function contributing to neurodegenerative processes.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
12% SDS PAGE
All lanes: Western blot - Anti-UCP4 antibody (AB183886) at 1/1000 dilution
Lane 1: SK-N-SH whole cell lysate at 30 µg
Lane 2: IMR32 whole cell lysate at 30 µg
Lane 3: SK-N-AS whole cell lysate at 30 µg
Predicted band size: 36 kDa
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com