Anti-UCP4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The protein UCP4 also known as Uncoupling Protein 4 or SLC25A27 is part of the mitochondrial inner membrane and operates mechanically to dissipate the proton gradient. This action decreases the mitochondrial membrane potential. UCP4 has a molecular mass of approximately 36 kDa. This protein is highly expressed in brain tissue particularly within the central nervous system where it plays an important role in energy regulation.

Biological function summary

UCP4 mediates heat production by uncoupling oxidative phosphorylation. UCP4 participates in reducing reactive oxygen species production within cells by regulating the mitochondrial respiration rate. It functions as part of a protein family consisting of other uncoupling proteins such as UCP1 UCP2 and UCP3. This family collectively contributes to the non-shivering thermogenesis process a mechanism essential for maintaining body temperature and metabolic efficiency.

Pathways

UCP4 takes part in the regulation of energy metabolism and is involved in adaptive thermogenesis. Within these energy metabolism pathways UCP4 interacts with proteins involved in the control of cellular energy expenditure and homeostasis. It works in conjunction with UCP2 and UCP3 to regulate metabolic rates and energy balance influencing processes such as the glycolysis pathway to adapt energy production to the physiological needs of the organism.

Associated diseases and disorders

UCP4 has associations with neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. It regulates mitochondrial dysfunction which is a characteristic feature of these disorders. In Alzheimer’s disease UCP4 may interact with proteins like amyloid precursor protein (APP) that play a role in disease pathology. Its dysregulation can lead to impaired mitochondrial function contributing to neurodegenerative processes.