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AB183886

Anti-UCP4 antibody

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(4 Publications)

Rabbit Polyclonal UCP4 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A27 aa 1-200.

View Alternative Names

UCP4, UNQ772/PRO1566, SLC25A27, Mitochondrial uncoupling protein 4, UCP 4, Solute carrier family 25 member 27

1 Images
Western blot - Anti-UCP4 antibody (AB183886)
  • WB

Supplier Data

Western blot - Anti-UCP4 antibody (AB183886)

12% SDS PAGE

All lanes:

Western blot - Anti-UCP4 antibody (ab183886) at 1/1000 dilution

Lane 1:

SK-N-SH whole cell lysate at 30 µg

Lane 2:

IMR32 whole cell lysate at 30 µg

Lane 3:

SK-N-AS whole cell lysate at 30 µg

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SLC25A27 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

O95847

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein UCP4 also known as Uncoupling Protein 4 or SLC25A27 is part of the mitochondrial inner membrane and operates mechanically to dissipate the proton gradient. This action decreases the mitochondrial membrane potential. UCP4 has a molecular mass of approximately 36 kDa. This protein is highly expressed in brain tissue particularly within the central nervous system where it plays an important role in energy regulation.
Biological function summary

UCP4 mediates heat production by uncoupling oxidative phosphorylation. UCP4 participates in reducing reactive oxygen species production within cells by regulating the mitochondrial respiration rate. It functions as part of a protein family consisting of other uncoupling proteins such as UCP1 UCP2 and UCP3. This family collectively contributes to the non-shivering thermogenesis process a mechanism essential for maintaining body temperature and metabolic efficiency.

Pathways

UCP4 takes part in the regulation of energy metabolism and is involved in adaptive thermogenesis. Within these energy metabolism pathways UCP4 interacts with proteins involved in the control of cellular energy expenditure and homeostasis. It works in conjunction with UCP2 and UCP3 to regulate metabolic rates and energy balance influencing processes such as the glycolysis pathway to adapt energy production to the physiological needs of the organism.

UCP4 has associations with neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. It regulates mitochondrial dysfunction which is a characteristic feature of these disorders. In Alzheimer’s disease UCP4 may interact with proteins like amyloid precursor protein (APP) that play a role in disease pathology. Its dysregulation can lead to impaired mitochondrial function contributing to neurodegenerative processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated.
See full target information SLC25A27
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cellular neuroscience 19:1603657 PubMed40958776

2025

APOE genotype-dependent differences in human astrocytic energy metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Vanessa Budny,Chantal Bodenmann,Kathrin J Zürcher,Maik Krüger,Sherida M de Leeuw,Rebecca Z Weber,Ruslan Rust,Luca Ravotto,Iván Ruminot,L Felipe Barros,Bruno Weber,Christian Tackenberg

Journal of virology 98:e0109924 PubMed39480111

2024

HCMV strain- and cell type-specific alterations in membrane contact sites point to the convergent regulation of organelle remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

William A Hofstadter,Ji Woo Park,Krystal K Lum,Sophia Chen,Ileana M Cristea

Biology of sex differences 14:65 PubMed37770961

2023

Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain.

Applications

Unspecified application

Species

Unspecified reactive species

Sumit Jamwal,Jennifer K Blackburn,John D Elsworth

Cell death & disease 13:406 PubMed35468877

2022

Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairment.

Applications

Unspecified application

Species

Unspecified reactive species

Manman Zhang,Wenliang Gong,Dianjun Zhang,Ming Ji,Binjie Chen,Beina Chen,Xinyu Li,Yuefei Zhou,Chengyi Dong,Gehua Wen,Xiaoni Zhan,Xiafang Wu,Lulu Cui,Yuliang Feng,Siman Wang,Huiya Yuan,Enyu Xu,Maosheng Xia,Alexei Verkhratsky,Baoman Li
View all publications
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