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Rabbit Polyclonal UCP4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A27 aa 1-200.

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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human SLC25A27 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link O95847
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Target data

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

Alternative names

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Rabbit Polyclonal UCP4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A27 aa 1-200.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen

Recombinant Fragment Protein within Human SLC25A27 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Database link O95847

Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological summary

UCP4 mediates heat production by uncoupling oxidative phosphorylation. UCP4 participates in reducing reactive oxygen species production within cells by regulating the mitochondrial respiration rate. It functions as part of a protein family consisting of other uncoupling proteins such as UCP1 UCP2 and UCP3. This family collectively contributes to the non-shivering thermogenesis process a mechanism essential for maintaining body temperature and metabolic efficiency.

Mechanical summary

The protein UCP4 also known as Uncoupling Protein 4 or SLC25A27 is part of the mitochondrial inner membrane and operates mechanically to dissipate the proton gradient. This action decreases the mitochondrial membrane potential. UCP4 has a molecular mass of approximately 36 kDa. This protein is highly expressed in brain tissue particularly within the central nervous system where it plays an important role in energy regulation.

Pathway

UCP4 takes part in the regulation of energy metabolism and is involved in adaptive thermogenesis. Within these energy metabolism pathways UCP4 interacts with proteins involved in the control of cellular energy expenditure and homeostasis. It works in conjunction with UCP2 and UCP3 to regulate metabolic rates and energy balance influencing processes such as the glycolysis pathway to adapt energy production to the physiological needs of the organism.

Disease

UCP4 has associations with neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. It regulates mitochondrial dysfunction which is a characteristic feature of these disorders. In Alzheimer’s disease UCP4 may interact with proteins like amyloid precursor protein (APP) that play a role in disease pathology. Its dysregulation can lead to impaired mitochondrial function contributing to neurodegenerative processes.

Product promise

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1 product image

  • Western blot - Anti-UCP4 antibody (ab183886), expandable thumbnail

    Western blot - Anti-UCP4 antibody (ab183886)

    12% SDS PAGE

    All lanes: Western blot - Anti-UCP4 antibody (AB183886) at 1/1000 dilution

    Lane 1: SK-N-SH whole cell lysate at 30 µg

    Lane 2: IMR32 whole cell lysate at 30 µg

    Lane 3: SK-N-AS whole cell lysate at 30 µg

    Predicted band size: 36 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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