Rabbit Polyclonal UGGT2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human UGGT2 aa 650-1200.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human UGGT2 aa 650-1200. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NYU1
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Target data
Function
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Alternative names
UGCGL2, UGT2, UGGT2, UDP-glucose:glycoprotein glucosyltransferase 2, hUGT2, UDP--Glc:glycoprotein glucosyltransferase 2, UDP-glucose ceramide glucosyltransferase-like 1
Recommended products
Rabbit Polyclonal UGGT2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human UGGT2 aa 650-1200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human UGGT2 aa 650-1200. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NYU1
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
UGGT2 also known as UDP-glucose glycoprotein glucosyltransferase 2 is an enzyme involved in protein quality control. It plays a mechanical role in the glycoprotein folding process by adding glucose to improperly folded glycoproteins. The molecular weight of UGGT2 is approximately 170 kilodaltons. It is expressed in a variety of tissues with notable presence in the endoplasmic reticulum.
- Biological function summary
UGGT2 functions to ensure proper glycoprotein folding and stability. It is essential in the calnexin/calreticulin cycle a chaperone system in the endoplasmic reticulum where it selectively glucosylates misfolded glycoproteins. This process permits the recognition and binding of these glycoproteins by the chaperone proteins calnexin and calreticulin assisting their proper refolding or targeting them for degradation if refolding fails.
- Pathways
UGGT2 is integrated into the endoplasmic reticulum-associated degradation (ERAD) and the unfolded protein response (UPR) pathways. Within the ERAD pathway UGGT2 works in conjunction with other proteins like EDEM1 to recognize and retain misfolded glycoproteins for further processing. In the UPR pathway UGGT2 plays a role in maintaining cellular homeostasis by managing the load of unfolded proteins which is important in the response to cellular stress.
- Associated diseases and disorders
UGGT2 is connected to conditions related to protein misfolding and cellular stress such as neurodegenerative diseases. Aberrant function of UGGT2 may contribute to diseases like Alzheimer's disease where protein aggregates are prevalent. It also interacts with proteins such as APP implicated in neurodegeneration showcasing its significance in understanding these disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-UGGT2 antibody (ab154683)
5% SDS PAGE
All lanes: Western blot - Anti-UGGT2 antibody (ab154683) at 1/1000 dilution
All lanes: HeLa whole cell lysate at 30 µg/mL
Predicted band size: 175 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGGT2 antibody (ab154683)
Immunohistochemical analysis of paraffin-embedded U87 xenograft tissue labeling UGGT2 with ab154683 at 1/500 dilution.
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