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AB192424

Anti-UGT1A4 antibody

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(2 Publications)

Rabbit Polyclonal UGT1A4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human UDP-glucuronosyltransferase 1A4.

View Alternative Names

GNT1, UGT1, UGT1A4, UDP-glucuronosyltransferase 1A4, Bilirubin-specific UDPGT isozyme 2, UDP-glucuronosyltransferase 1-4, UDP-glucuronosyltransferase 1-D, hUG-BR2, UDPGT 1-4, UGT1*4, UGT1-04, UGT1.4, UGT-1D, UGT1D

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human UDP-glucuronosyltransferase 1A4.

P22310

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab192424 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UGT1A4 also known as UDP-glucuronosyltransferase 1A4 is an enzyme that plays a significant role in drug metabolism. It weighs approximately 61 kDa. UGT1A4 catalyzes the glucuronidation process where it transfers glucuronic acid from UDP-glucuronic acid to substrates making them more water-soluble and easier to excrete. This process mainly occurs in the liver where UGT1A4 expression is high but expression is also found in other tissues like the kidney.
Biological function summary

UGT1A4 functions in the detoxification and metabolism of various endogenous and exogenous compounds. It is not a part of a complex. It primarily metabolizes drugs such as antipsychotics and anticonvulsants moving them towards elimination from the body. UGT1A4 facilitates the detoxification of hormones like bile acids and steroid hormones by making them more hydrophilic.

Pathways

UGT1A4 participates in the glucuronidation pathway an important phase II metabolism pathway. This pathway is essential for the clearance of drugs and xenobiotic compounds. UGT1A4 interacts with other UDP-glucuronosyltransferase family members contributing to the complex network of detoxification pathways. It often works alongside cytochrome P450 enzymes which are important for the preceding phase I metabolism.

Altered function or expression of UGT1A4 associates with drug-induced toxicity and liver disorders. Individuals with polymorphisms in UGT1A4 may experience adverse drug reactions or altered drug efficacy. UGT1A4's interaction with enzymes like CYP2C9 can impact the metabolism of drugs like anticonvulsants potentially contributing to side effects or treatment failure in epilepsy management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed : 18177842, PubMed : 24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed : 18177842). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed : 24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed : 18177842).. Isoform 2. Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
See full target information UDP-glucuronosyltransferase 1A4
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature metabolism 4:739-758 PubMed35760869

2022

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Shuijie Li,Wenyu Li,Juan Yuan,Petra Bullova,Jieyu Wu,Xuepei Zhang,Yong Liu,Monika Plescher,Javier Rodriguez,Oscar C Bedoya-Reina,Paulo R Jannig,Paula Valente-Silva,Meng Yu,Marie Arsenian Henriksson,Roman A Zubarev,Anna Smed-Sörensen,Carolyn K Suzuki,Jorge L Ruas,Johan Holmberg,Catharina Larsson,C Christofer Juhlin,Alex von Kriegsheim,Yihai Cao,Susanne Schlisio

Frontiers in pharmacology 10:1111 PubMed31611795

2019

Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR.

Applications

Unspecified application

Species

Unspecified reactive species

Na Yao,Caiwen Zeng,Tao Zhan,Fang He,Mingyi Liu,Fanglan Liu,Hong Zhang,Yuqing Xiong,Chunhua Xia
View all publications
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