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AB97646

Anti-UGT1A6 antibody

3

(2 Reviews)

|

(2 Publications)

Rabbit Polyclonal UGT1A6 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

GNT1, UGT1, UGT1A6, UDP-glucuronosyltransferase 1-6, UDPGT 1-6, UGT1*6, UGT1-06, UGT1.6, Phenol-metabolizing UDP-glucuronosyltransferase, UDP-glucuronosyltransferase 1-F, UDP-glucuronosyltransferase 1A6, UGT-1F, UGT1F

2 Images
Western blot - Anti-UGT1A6 antibody (AB97646)
  • WB

Supplier Data

Western blot - Anti-UGT1A6 antibody (AB97646)

Samples were separated by 7.5% SDS PAGE.

All lanes:

Western blot - Anti-UGT1A6 antibody (ab97646) at 1/1000 dilution

Lane 1:

293T whole cell lysates at 30 µg

Lane 2:

A431 whole cell lysates at 30 µg

Lane 3:

HeLa whole cell lysates at 30 µg

Lane 4:

HepG2 whole cell lysates at 30 µg

Predicted band size: 61 kDa

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Western blot - Anti-UGT1A6 antibody (AB97646)
  • WB

Unknown

Western blot - Anti-UGT1A6 antibody (AB97646)

7.5% SDS PAGE

All lanes:

Western blot - Anti-UGT1A6 antibody (ab97646) at 1/1000 dilution

Lane 1:

A431 whole cell lysate at 30 µg

Lane 2:

H1299 whole cell lysate at 30 µg

Predicted band size: 61 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UGT1A6 also known as UDP-glucuronosyltransferase 1A6 is an enzyme involved in the glucuronidation process which is critical for detoxifying and eliminating compounds from the body. This enzyme has a molecular mass of approximately 55 kDa. It is widely expressed in the liver as well as in the intestine and kidney where it catalyzes the transfer of glucuronic acid to various substrates. The enzyme achieves this by transforming small lipophilic molecules into more water-soluble forms for easier excretion.
Biological function summary

The UGT1A6 enzyme functions in the phase II metabolism of various endogenous and exogenous substrates contributing to the body's defense mechanism. It is part of the larger UGT1A gene complex which includes several other UGT enzymes that share exon regions highlighting their evolutionary versatility. UGT1A6 primarily catalyzes the conjugation of planar phenols such as acetaminophen and a variety of other phenolic and aromatic amines. Through these activities the enzyme plays an integral role in maintaining metabolic balance.

Pathways

UGT1A6 operates within detoxification and drug metabolism pathways including glucuronidation pathways for processing drugs and toxins. It interacts with cytochrome P450 enzymes which help in oxidative metabolism providing substrates for UGT1A6 to convert into more polar metabolites. The conjugative actions of UGT1A6 in these pathways facilitate efficient elimination of potentially harmful compounds and maintain metabolic homeostasis.

Mutations or altered expression of UGT1A6 can impact the body's drug-processing capabilities contributing to diseases such as Gilbert's syndrome and possible drug toxicity. In Gilbert's syndrome there is often a connection with UGT1A1 another UGT family enzyme leading to elevated levels of unconjugated bilirubin in the blood. UGT1A6's role in drug metabolism suggests that it may influence conditions related to drug sensitivity and resistance making it a significant factor in pharmacogenomics and personalized medicine approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
See full target information UDP-glucuronosyltransferase 1-6
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Evidence-based complementary and alternative medicine : eCAM 2020:2696432 PubMed33273950

2020

Green Tea Polyphenols Protect against Acetaminophen-Induced Liver Injury by Regulating the Drug Metabolizing Enzymes and Transporters.

Applications

Unspecified application

Species

Unspecified reactive species

Le Lv,Chenshu Xu,Xiaoye Mo,Hai-Yan Sun,Huichang Bi

The Journal of pharmacology and experimental therapeutics 344:244-52 PubMed23055538

2012

Regulation of hepatic phase II metabolism in pregnant mice.

Applications

WB

Species

Mouse

Xia Wen,Ajay C Donepudi,Paul E Thomas,Angela L Slitt,Roberta S King,Lauren M Aleksunes
View all publications
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Product promise

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