Rabbit Polyclonal UGT2B10 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human UGT2B10 aa 1-300.
Images
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human UGT2B10 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P36537
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/200.00000 | Notes - |
Target data
Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Alternative names
UDP-glucuronosyltransferase 2B10, UDPGT 2B10, UGT2B10
Recommended products
Rabbit Polyclonal UGT2B10 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human UGT2B10 aa 1-300.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human UGT2B10 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P36537
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
UGT2B10 also known as UDP-glucuronosyltransferase 2B10 is a member of the UGT2B subfamily. The enzyme has a molecular weight of approximately 63 kDa. UGT2B10 is involved in glucuronidation a process adding glucuronic acid to various substrates for detoxification and excretion. This enzyme is mainly expressed in human liver but also found in other tissues such as the kidney intestine and lung.
- Biological function summary
UGT2B10 facilitates the metabolism of several endogenous and exogenous compounds including drugs and hormones. It serves an important role in the conjugation and elimination of bile acids steroid hormones and certain carcinogens. UGT2B10 does not function in isolation but interacts with other enzymes in the UGT family to maintain homeostasis of these substances within the body.
- Pathways
UGT2B10 plays an important role in the drug metabolism and detoxification pathways. It is actively engaged in the glucuronidation pathway collaborating with other UGT enzymes like UGT1A1. This pathway is essential for reducing the activity and enhancing the solubility of various pharmacological compounds facilitating their renal and biliary excretion.
- Associated diseases and disorders
UGT2B10 has associations with liver disease and certain forms of cancer. Its decreased activity can contribute to impaired drug metabolism affecting drug efficacy and safety in patients with liver cirrhosis. Abnormal UGT2B10 expression or function could also influence carcinogen metabolism potentially affecting cancer risk. The enzyme connects with other detoxifying proteins in the liver affecting the overall detoxification process and disease outcomes.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGT2B10 antibody (ab225931)
Paraffin-embedded human ovarian cancer tissue stained for UGT2B10 using ab225931 at 1/100 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGT2B10 antibody (ab225931)
Paraffin-embedded human cervical cancer tissue stained for UGT2B10 using ab225931 at 1/100 dilution in immunohistochemical analysis.
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