AB154864

Anti-UGT2B15 antibody [EPR10615(B)]

RabMAb
Recombinant
What is this?

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(3 Publications)

Rabbit Recombinant Monoclonal UGT2B15 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

UGT2B8, UGT2B15, UDP-glucuronosyltransferase 2B15, UDPGT 2B15, HLUG4, UDP-glucuronosyltransferase 2B8, UDPGTh-3, UDPGT 2B8

1 Images

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Western blot - Anti-UGT2B15 antibody [EPR10615(B)] (AB154864)

All lanes:

Western blot - Anti-UGT2B15 antibody [EPR10615(B)] (ab154864) at 1/1000 dilution

All lanes:

LnCap cell lysate at 10 µg

Predicted band size: 61 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10615(B)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UGT2B15 also known as UDP-glucuronosyltransferase 2B15 plays an important role in the glucuronidation process. This enzyme belongs to the UDP-glycosyltransferase family and facilitates the attachment of glucuronic acid to small lipophilic molecules making them more water-soluble. UGT2B15 has a mass of approximately 56 kDa and finds its expression mainly in the liver but also in other tissues such as the prostate and testis. This distribution suggests its importance in the metabolism of various endogenous and exogenous compounds.

Biological function summary

Enzymes like UGT2B15 are important in the detoxification of substances. UGT2B15 facilitates the metabolism and clearance of steroid hormones including androgens and nonsteroids such as drugs. It does not operate as part of a larger complex but works individually to modify substrates. This process converts lipophilic drugs and hormones into more excretable forms aiding in homeostasis.

Pathways

UGT2B15 functions within important metabolic pathways such as steroid metabolism and drug detoxification pathways. In these pathways it interacts with other UGT family members such as UGT2B17 to ensure the efficient metabolism of various substrates. Their actions help regulate steroid levels and detoxify therapeutic drugs keeping physiological functions balanced by preventing the accumulation of potentially harmful compounds.

Researchers associate UGT2B15 with conditions like prostate cancer and drug resistance. Altered expression or function of this enzyme may contribute to the development and progression of prostate cancer by affecting androgen metabolism. Additionally UGT2B15 plays a role in drug resistance often seen in therapies involving anti-cancer agents that require metabolic activation for clearance. Its activity connects with related proteins such as UGT2B17 influencing the progression and treatment responses in these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed : 16595710, PubMed : 18719240, PubMed : 23288867, PubMed : 7835232, PubMed : 9295060). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed : 7835232). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed : 16595710, PubMed : 18719240, PubMed : 23288867, PubMed : 7835232, PubMed : 9295060). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed : 7835232). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity).

See full target information UGT2B15

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of ovarian research 18:13 PubMed39856707

2025

Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers.

Applications

Unspecified application

Species

Unspecified reactive species

Xiufen Zheng,Zikai Chen,Miao Liang,Liting Zhou,Miaoru Wang,Silin Zhang,Shuyun Zhang,Lei Ma,Wei Yi,Xiawen Liu

Oncology reports 40:1855-1862 PubMed30066917

2018

Bioinformatic analysis suggests that UGT2B15 activates the Hippo‑YAP signaling pathway leading to the pathogenesis of gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xuanmin Chen,Defeng Li,Nannan Wang,Meifeng Yang,Aijun Liao,Shuling Wang,Guangsheng Hu,Bing Zeng,Yuhong Yao,Diqun Liu,Han Liu,Weiwei Zhou,Weisheng Xiao,Peiyuan Li,Chen Ming,Song Ping,Pingfang Chen,Li Jing,Yu Bai,Jun Yao

Cancer cell 32:792-806.e7 PubMed29153843

2017

Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Shipra Shukla,Joanna Cyrta,Devan A Murphy,Edward G Walczak,Leili Ran,Praveen Agrawal,Yuanyuan Xie,Yuedan Chen,Shangqian Wang,Yu Zhan,Dan Li,Elissa W P Wong,Andrea Sboner,Himisha Beltran,Juan Miguel Mosquera,Jessica Sher,Zhen Cao,John Wongvipat,Richard P Koche,Anuradha Gopalan,Deyou Zheng,Mark A Rubin,Howard I Scher,Ping Chi,Yu Chen

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-UGT2B15 antibody [EPR10615(B)]

Western blot - Anti-UGT2B15 antibody [EPR10615(B)] (AB154864)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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