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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Recombinant Monoclonal ULBP1 antibody. Suitable for Flow Cyt and reacts with Human samples.
IgG
Rabbit
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Liquid
Monoclonal
IP | Flow Cyt | WB | IHC-P | ICC/IF | |
---|---|---|---|---|---|
Human | Not recommended | Tested | Not recommended | Not recommended | Not recommended |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/60 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info - | Notes - |
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
UL16-binding protein 1, ALCAN-beta, NKG2D ligand 1, Retinoic acid early transcript 1I, N2DL-1, NKG2DL1, RAET1I, N2DL1, ULBP1
Rabbit Recombinant Monoclonal ULBP1 antibody. Suitable for Flow Cyt and reacts with Human samples.
UL16-binding protein 1, ALCAN-beta, NKG2D ligand 1, Retinoic acid early transcript 1I, N2DL-1, NKG2DL1, RAET1I, N2DL1, ULBP1
IgG
Rabbit
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Liquid
Monoclonal
EPR22088-211
Affinity purification Protein A
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
This protein plays a critical role in immune surveillance and response to malignancies and infections. ULBP1 does not form a complex on its own but it works closely with other NKG2D ligands contributing to the immune system's ability to recognize and eliminate abnormal cells. Its presence can enhance immune cell-mediated cytotoxicity indicating its role in immune defense.
ULBP1 also known as UL16-binding protein 1 is a member of the MHC class I-related molecules. It weighs approximately 28 kDa. ULBP1 acts mechanically as a ligand for the NKG2D receptor part of the activating receptor on natural killer (NK) cells and certain T cells. It is primarily expressed on the surface of various cells including epithelial and some tumor cells. Its expression can be induced by cellular stress or infection.
The protein takes an active part in the immune system activation interacting notably within the NK cell-mediated cytotoxicity pathway. It functions alongside other NKG2D ligands like MICA/MICB to modulate the activity of NK cells and T cells. This connection to the NKG2D pathway ensures a critical interface between innate and adaptive immunity reinforcing defense against infected or tumor cells.
Researchers have noted associations between ULBP1 and cancer progression or immune evasion. Its upregulation on tumor cells can lead to tumor clearance; however some cancers may shed ULBP1 to escape immune detection. In autoimmune diseases such as rheumatoid arthritis altered expression of ULBP1 and its interaction with NKG2D can potentially exacerbate inflammation. These interactions emphasize the balance that ULBP1 maintains in managing immune responses and its implications in pathology.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Flow cytometric analysis of Human peripheral blood mononuclear (PBMC) cells labelling ULBP1 with ab224711 at 1/60 dilution (Right) compared with a Rabbit monoclonal IgG (ab172730, Left) isotype control. Goat anti rabbit IgG (Alexa Fluor® 488, ab150097) at 1/5000 dilution was used as the secondary antibody.
Cells were stained with rabbit IgG (Left) or ab224711 (Right). Then stained with anti-CD14 conjugated to BV510. Gated on viable cells.
Flow cytometric analysis of HaCaT (Human skin keratinocyte, Left) / MOLT-4 (Human lymphoblastic leukemia T lymphoblast, Right) cells labelling ULBP1 with ab224711 at 1/60 dilution (Red) compared with a Rabbit monoclonal IgG (ab172730, Black) isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (Blue). Goat anti rabbit IgG (Alexa Fluor® 488, ab150077) at 1/2000 dilution was used as the secondary antibody.
Negative control: HaCaT. (PMID: 22316211) Gated on viable cells.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com