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AB89930

Anti-ULBP2 antibody [MM0593-7F33]

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(4 Publications)

Mouse Monoclonal ULBP2 antibody. Carrier free. Suitable for Flow Cyt, FuncS (Neut/Block) and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ULBP2.

View Alternative Names

N2DL2, RAET1H, UNQ463/PRO791, ULBP2, UL16-binding protein 2, ALCAN-alpha, NKG2D ligand 2, Retinoic acid early transcript 1H, N2DL-2, NKG2DL2

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0593-7F33

Isotype

IgG2a

Carrier free

Yes

Reacts with

Human

Applications

FuncS (Neut/Block), Flow Cyt

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ULBP2.

Q9BZM5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg2c-kappa-monoclonal-18c8bc7ad10-isotype-control-ab170191'>ab170191</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ULBP2 also known as UL16-binding protein 2 and N2DL2 is a glycoprotein with a mass of approximately 30 kDa. It belongs to the family of NKG2D ligands and plays an essential role in the immune response. This protein is expressed on the surface of a variety of cells including epithelial cells fibroblasts and activated immune cells. Its expression can be induced by cellular stress infection or transformation making it an important player in the regulation of the immune system.
Biological function summary

The function of ULBP2 is to facilitate the activation of natural killer (NK) cells and cytotoxic T lymphocytes through binding to the NKG2D receptor. ULBP2 is not a part of a complex but acts independently to trigger immune responses. By interacting with NKG2D ULBP2 promotes the release of cytokines and enhances the cytolytic activity of these immune cells leading to the destruction of infected or transformed cells. This mechanism allows the immune system to efficiently target and eliminate compromised cells.

Pathways

The interaction between ULBP2 and the NKG2D receptor forms a critical part of the immune surveillance pathway. This pathway detects and responds to cellular abnormalities such as tumorigenesis or viral infections. ULBP2's activity relates closely with other NKG2D ligands and components of the immune checkpoint pathways notably involving proteins like MICA and MICB. Additionally ULBP2’s interaction impacts the balance between activating and inhibitory signals within the NK cell cascade thereby influencing immune system homeostasis.

ULBP2 expression has significant implications in cancer and autoimmune conditions. Elevated levels of ULBP2 are frequently associated with various types of cancer where they can either stimulate anti-tumor immunity or be shed to evade immune detection. In this context the protein interacts with NKG2D which is also expressed on tumor-infiltrating lymphocytes. Additionally altered expression of ULBP2 has been observed in inflammatory disorders potentially contributing to tissue damage due to sustained immune activation. Understanding these interactions is important for developing therapeutic strategies targeting ULBP2-related pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
See full target information ULBP2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:597 PubMed40775202

2025

ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation.

Applications

Unspecified application

Species

Unspecified reactive species

Wentao Zhang,Wen Ren,Shuyan Guo,Haobo Han,Weiwen Cai,Haowen Bai,Long Li,Xiangyan Jiang,Xin Zheng,Tiansheng Zhang,Yan Wang,Huili Ye,Hongtai Cao,Wengui Shi,Huinian Zhou,Zeyuan Yu,Long Qin,Zuoyi Jiao

Oncoimmunology 6:e1358839 PubMed29147621

2017

In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Guranda Chitadze,Charlotte Flüh,Elgar Susanne Quabius,Sandra Freitag-Wolf,Christian Peters,Marcus Lettau,Jaydeep Bhat,Daniela Wesch,Hans-Heinrich Oberg,Stefanie Luecke,Ottmar Janssen,Michael Synowitz,Janka Held-Feindt,Dieter Kabelitz

Oncoimmunology 5:e1093276 PubMed27141377

2016

NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors.

Applications

Flow Cyt

Species

Unspecified reactive species

Guranda Chitadze,Marcus Lettau,Stefanie Luecke,Ting Wang,Ottmar Janssen,Daniel Fürst,Joannis Mytilineos,Daniela Wesch,Hans-Heinrich Oberg,Janka Held-Feindt,Dieter Kabelitz

Frontiers in oncology 3:94 PubMed23626949

2013

In vitro Natural Killer Cell Immunotherapy for Medulloblastoma.

Applications

Flow Cyt

Species

Human

Lucia Fernández,Raquel Portugal,Jaime Valentín,Roberto Martín,Hannah Maxwell,Marta González-Vicent,Miguel Ángel Díaz,Inmaculada de Prada,Antonio Pérez-Martínez
View all publications
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