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AB106341

Anti-Ultraspiracle antibody

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(2 Publications)

Rabbit Polyclonal USP antibody. Suitable for ICC, WB and reacts with Drosophila melanogaster samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Silkworm USP.

View Alternative Names

Cf1, NR2B4, CG4380, usp, Protein ultraspiracle, Chorion factor 1, Nuclear receptor subfamily 2 group B member 4, XR2C

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Drosophila melanogaster

Applications

ICC, WB

applications

Immunogen

Synthetic Peptide within Silkworm USP. The exact immunogen used to generate this antibody is proprietary information.

P49700

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Drosophila melanogaster": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ultraspiracle also known as USP is a nuclear receptor that acts as a transcription factor. It is important in insects often found within the ecdysone receptor complex which occurs in heterodimer form with the Ecdysone receptor (EcR). The protein's mass is approximately 54 kDa. Ultraspiracle generally expresses in insect cells playing an essential role in development and metamorphosis. As part of the ecdysone receptor complex USP binds to specific DNA sequences and regulates gene expression in response to hormonal signaling.
Biological function summary

The ecdysone receptor complex including Ultraspiracle has a significant role in the process of insect molting and metamorphosis. Ultraspiracle as part of this heterodimer with EcR binds to ecdysone response elements on DNA leading to the activation of specific genes necessary for development. This interaction influences various biological processes such as cell cycle regulation and programmed cell death which are important during the transition from larva to pupa and finally to an adult insect.

Pathways

The ecdysone receptor complex involves Ultraspiracle and EcR in the ecdysone signaling pathway which regulates insect development and metamorphosis. The pathway is key in controlling the expression of genes that determine molting and differentiation during developmental stages. USP and EcR interact with other transcription factors and co-regulators to fine-tune the gene expression profiles necessary for these processes. Additionally interactions with proteins like Heat Shock Protein 90 (Hsp90) assist in stabilizing the ecdysone receptor complex ensuring proper signaling.

Ultraspiracle serves as a potential target for research into insect growth regulators aimed at controlling pest species. Modulating the USP activity can disrupt normal development in pests reducing their ability to mature and reproduce. Additionally since USP connects with EcR in hormonal pathways targeting this interaction could lead to novel pesticides that are more specific and environmentally friendly. By understanding the function and interactions of Ultraspiracle researchers can explore new methods for pest control and management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene.
See full target information usp
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

PLoS genetics 13:e1006788 PubMed28493870

2017

Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Vandana Sharma,Anuj K Pandey,Ajay Kumar,Snigdha Misra,Himanshu P K Gupta,Snigdha Gupta,Anshuman Singh,Norene A Buehner,Kristipati Ravi Ram

Nature communications 8:14806 PubMed28378812

2017

EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes.

Applications

WB

Species

Unspecified reactive species

Judith Kreher,Kristina Kovač,Karim Bouazoune,Igor Mačinković,Anna Luise Ernst,Erik Engelen,Roman Pahl,Florian Finkernagel,Magdalena Murawska,Ikram Ullah,Alexander Brehm
View all publications
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