Rabbit Polyclonal USP antibody. Suitable for ICC, WB and reacts with Drosophila melanogaster samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Silkworm USP.
Constituents: Whole serum
| ICC | WB | |
|---|---|---|
| Drosophila melanogaster | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Drosophila melanogaster | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Drosophila melanogaster | Dilution info Use at an assay dependent concentration. | Notes - |
Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene.
Cf1, NR2B4, CG4380, usp, Protein ultraspiracle, Chorion factor 1, Nuclear receptor subfamily 2 group B member 4, XR2C
Rabbit Polyclonal USP antibody. Suitable for ICC, WB and reacts with Drosophila melanogaster samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Silkworm USP.
Constituents: Whole serum
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Ultraspiracle also known as USP is a nuclear receptor that acts as a transcription factor. It is important in insects often found within the ecdysone receptor complex which occurs in heterodimer form with the Ecdysone receptor (EcR). The protein's mass is approximately 54 kDa. Ultraspiracle generally expresses in insect cells playing an essential role in development and metamorphosis. As part of the ecdysone receptor complex USP binds to specific DNA sequences and regulates gene expression in response to hormonal signaling.
The ecdysone receptor complex including Ultraspiracle has a significant role in the process of insect molting and metamorphosis. Ultraspiracle as part of this heterodimer with EcR binds to ecdysone response elements on DNA leading to the activation of specific genes necessary for development. This interaction influences various biological processes such as cell cycle regulation and programmed cell death which are important during the transition from larva to pupa and finally to an adult insect.
The ecdysone receptor complex involves Ultraspiracle and EcR in the ecdysone signaling pathway which regulates insect development and metamorphosis. The pathway is key in controlling the expression of genes that determine molting and differentiation during developmental stages. USP and EcR interact with other transcription factors and co-regulators to fine-tune the gene expression profiles necessary for these processes. Additionally interactions with proteins like Heat Shock Protein 90 (Hsp90) assist in stabilizing the ecdysone receptor complex ensuring proper signaling.
Four words that are not the target name are insect populations and control affects pest-related challenges. Ultraspiracle serves as a potential target for research into insect growth regulators aimed at controlling pest species. Modulating the USP activity can disrupt normal development in pests reducing their ability to mature and reproduce. Additionally since USP connects with EcR in hormonal pathways targeting this interaction could lead to novel pesticides that are more specific and environmentally friendly. By understanding the function and interactions of Ultraspiracle researchers can explore new methods for pest control and management.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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