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AB69443

Anti-Unc93a antibody

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(2 Publications)

Rabbit Polyclonal Unc93a antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Protein unc-93 homolog A.

View Alternative Names

Protein unc-93 homolog A, HmUnc-93A, Unc-93A, UNC93A

1 Images
Western blot - Anti-Unc93a antibody (AB69443)
  • WB

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Western blot - Anti-Unc93a antibody (AB69443)

Lane 1:

Western blot - Anti-Unc93a antibody (ab69443) at 0.5 µg/mL

Lane 2:

Western blot - Anti-Unc93a antibody (ab69443) at 1 µg/mL

All lanes:

HeLa cell lysate at 15 µg

Predicted band size: 50 kDa

Observed band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Protein unc-93 homolog A. The exact immunogen used to generate this antibody is proprietary information.

Q86WB7

Specificity

ab69443 will not cross-react with Unc93b.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Unc93a protein sometimes referred to as Unc-93 Homolog A plays an important role in cellular processes. It is a protein with a molecular mass of approximately 67 kDa. Unc93a expresses mainly in various tissues suggesting its involvement in multiple physiological functions across different organ systems. It has been identified in the endoplasmic reticulum where it participates in unfolding protein response.
Biological function summary

Unc93a facilitates various essential cellular activities by acting as a part of a larger protein complex. Its primary role involves the regulation of immune responses and the proper functioning of immune cell signaling. The protein is important for maintaining the stability and function of membrane-associated proteins involved in these pathways. Unc93a contributes to the healthy communication within immune cells by modulating how they react to external signals.

Pathways

The Unc93a protein is integral to the immune response signaling pathways such as TLR (Toll-like receptor) signaling. It works closely with other proteins like MyD88 and TRIF which are essential mediators of signal transduction in this pathway. These interactions allow Unc93a to modulate the body’s response to pathogens ensuring effective immune defense mechanisms are in place.

Unc93a plays a significant role in autoimmune diseases such as systemic lupus erythematosus and inflammatory conditions like Crohn's disease. It links to these conditions through its interaction with proteins like TLR7 and TLR9 which are components of the immune response pathways. Dysregulation of Unc93a can lead to inappropriate immune responses contributing to the pathology of these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Protein unc-93 homolog A
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 8:579 PubMed32733888

2020

Glucose Availability Alters Gene and Protein Expression of Several Newly Classified and Putative Solute Carriers in Mice Cortex Cell Culture and .

Applications

Unspecified application

Species

Unspecified reactive species

Mikaela M Ceder,Emilia Lekholm,Axel Klaesson,Rekha Tripathi,Nadine Schweizer,Lydia Weldai,Sourabh Patil,Robert Fredriksson

Frontiers in molecular neuroscience 10:351 PubMed29163028

2017

The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Mikaela M Ceder,Emilia Lekholm,Sofie V Hellsten,Emelie Perland,Robert Fredriksson
View all publications
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