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AB221353

Anti-UNCX antibody

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(1 Publication)

Rabbit Polyclonal UNCX antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UNCX aa 150-250.

View Alternative Names

UNCX4.1, UNCX, Homeobox protein unc-4 homolog, Homeobox protein Uncx4.1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-UNCX antibody (AB221353)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-UNCX antibody (AB221353)

Immunfluorescent analysis of PFA fixed, Triton X-100 permeabilized NB-4 cells labeling UNCX with ab221353 at 4 μg/mL (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human UNCX aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

A6NJT0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UNCX also called UNC homeobox is a protein that functions as a transcription factor. It belongs to the HOX family and has a molecular mass of around 62 kDa. UNCX is mainly expressed in the central nervous system especially during embryonic development and in the neural and mesodermal tissues. Its expression is also observed in adult tissues although at lower levels. The protein plays key roles in developmental processes through its action as a transcription factor influencing gene expression.
Biological function summary

UNCX regulates the development of vertebrate axial skeletons and the neuromuscular system. It acts in embryogenesis ensuring proper vertebrae formation and influencing neurogenesis. UNCX functions as part of a transcriptional regulatory complex where it interacts with other proteins to control the transcription of specific target genes. These regulatory activities demonstrate its involvement in critical developmental stages and neural patterning.

Pathways

The transcription activities of UNCX influence the Notch signaling pathway and the Wnt signaling pathway. These pathways are essential in maintaining cellular differentiation and proliferation during development. UNCX interacts with proteins such as Notch receptors and β-catenin which are key components of these pathways. By coordinating with these proteins UNCX contributes to the fine-tuning of transcriptional responses during developmental processes.

Mutations or dysregulation of UNCX relate to congenital vertebral malformations and several neurodevelopmental disorders. For instance alterations in UNCX expression may contribute to defects in vertebral segmentation leading to disorders like scoliosis. Additionally aberrant activity of UNCX has associations with neural tube defects due to its ties with transcription factors like Pax6. Understanding its roles in such conditions may provide insights into potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).
See full target information UNCX
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:2203 PubMed38467616

2024

Mitochondrial metabolism sustains CD8 T cell migration for an efficient infiltration into solid tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Luca Simula,Mattia Fumagalli,Lene Vimeux,Irena Rajnpreht,Philippe Icard,Gary Birsen,Dongjie An,Frédéric Pendino,Adrien Rouault,Nadège Bercovici,Diane Damotte,Audrey Lupo-Mansuet,Marco Alifano,Marie-Clotilde Alves-Guerra,Emmanuel Donnadieu
View all publications
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