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Rabbit Recombinant Monoclonal UNQ511 antibody. Suitable for WB, IHC-P and reacts with Human samples.

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Images

Western blot - Anti-UNQ511 antibody [EPR23557-128] (AB270397), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] (AB270397), expandable thumbnail
  • Western blot - Anti-UNQ511 antibody [EPR23557-128] (AB270397), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] (AB270397), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Mouse
Not recommended
Not recommended
Rat
Not recommended
Not recommended

Tested
Tested

Species
Human
Dilution info
1/1000
Notes

-

Not recommended
Not recommended

Species
Mouse, Rat
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
1/250
Notes

-

Not recommended
Not recommended

Species
Mouse, Rat
Dilution info
-
Notes

-

Target data

Function

Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.

Alternative names

UNQ511/PRO1026, LYPD8, Ly6/PLAUR domain-containing protein 8

Recommended products

Rabbit Recombinant Monoclonal UNQ511 antibody. Suitable for WB, IHC-P and reacts with Human samples.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number
EPR23557-128
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

UNQ511 also known by alternative names is a protein that actively participates in cellular signaling processes. It exhibits a molecular mass of approximately 55 kDa. Researchers observe its expression in several tissues with particular focus on tissues with high metabolic activity. Its mechanical function includes engaging in signaling pathways providing vital communication links within and between cells contributing to the regulation of cellular responses to environmental stimuli.

Biological function summary

UNQ511 contributes to cellular homeostasis and energy metabolism within the cell. It forms interactions with several other proteins suggesting that it acts as part of a protein complex. This protein complex plays an important role in maintaining energy balance and regulating cellular growth processes. The presence of UNQ511 within these complexes allows it to influence critical cellular functions necessary for maintaining healthy cell cycles.

Pathways

UNQ511 is integrated into metabolic and intracellular signaling pathways. It closely interacts within the AMP-activated protein kinase (AMPK) pathway which is essential for cellular energy homeostasis. Additionally it associates with proteins like AMPK which links it to key cellular energy sensors indicating its role in energy regulation and metabolism. The interplay of UNQ511 within these pathways highlights its importance in energy balance and response to cellular stress.

Associated diseases and disorders

Scientific studies associate UNQ511 with metabolic disorders and certain types of cancer. Its interaction with AMPK and other metabolic regulators ties it to metabolic syndrome a condition involving dysregulated glucose metabolism. Furthermore alterations in its expression or function may contribute to cancer progression linking it to proteins known for oncogenic pathways. Understanding its role in these diseases could lead to the development of therapeutic interventions targeting these disorders.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

4 product images

  • Western blot - Anti-UNQ511 antibody [EPR23557-128] (ab270397), expandable thumbnail

    Western blot - Anti-UNQ511 antibody [EPR23557-128] (ab270397)

    Exposure time: 3 minutes

    The molecular weight observed is consistent with what has been described in the literature (PMID:27027293)

    All lanes: Western blot - Anti-UNQ511 antibody [EPR23557-128] (ab270397) at 1/1000 dilution

    Lane 1: Human colon tissue lysate at 20 µg

    Lane 2: Human colon cancer tissue lysate at 20 µg

    Secondary

    All lanes: Western blot - VeriBlot for IP Detection Reagent (HRP) (VeriBlot for IP Detection Reagent (HRP) ab131366) at 1/1000 dilution

    Predicted band size: 25 kDa

    Observed band size: 100 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] (ab270397), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] (ab270397)

    Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling UNQ511 with ab270397 at 1/250 dilution followed by a ready to use Goat Anti-Rabbit IgG H&L (HRP). Positive staining in apical surface of epithelial cells of human colon (PMID: 27027293) is observed. Counterstained with Hematoxylin

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is a ready to use Goat Anti-Rabbit IgG H&L (HRP).

  • Western blot - Anti-UNQ511 antibody [EPR23557-128] (ab270397), expandable thumbnail

    Western blot - Anti-UNQ511 antibody [EPR23557-128] (ab270397)

    Exposure time: 3 minutes

    The molecular weight observed is consistent with what has been described in the literature (PMID:27027293).

    All lanes: Western blot - Anti-UNQ511 antibody [EPR23557-128] (ab270397) at 1/1000 dilution

    Lane 1: Human large intestine tissue lysate at 20 µg

    Lane 2: Human large intestine tissue lysate treated with PNGase F at 20 µg

    Secondary

    All lanes: Western blot - VeriBlot for IP Detection Reagent (HRP) (VeriBlot for IP Detection Reagent (HRP) ab131366) at 1/1000 dilution

    Predicted band size: 25 kDa

    Observed band size: 100 kDa, 35 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] (ab270397), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] (ab270397)

    Immunohistochemical analysis of paraffin-embedded Human liver tissue labeling UNQ511 with ab270397 at 1/250 dilution (2 μg/ml) followed by a ready to use Goat Anti-Rabbit IgG H&L (HRP).

    Negative control: no staining in human liver (PMID: 27027293).

    Counterstained with Hematoxylin. Heat mediated antigen retrieval using Antigen Retrieval Buffer (100X Tris-EDTA Buffer, pH 9.0) ab93684 (Tris/EDTA buffer, pH 9.0)

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is a ready to use Goat Anti-Rabbit IgG H&L (HRP).

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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