AB270402

Anti-UNQ511 antibody [EPR23557-128] - BSA and Azide free

RabMAb
Recombinant
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Rabbit Recombinant Monoclonal UNQ511 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples.

View Alternative Names

UNQ511/PRO1026, LYPD8, Ly6/PLAUR domain-containing protein 8

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] - BSA and Azide free (AB270402)

IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] - BSA and Azide free (AB270402)

Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling UNQ511 with ab270397 at 1/250 dilution followed by a ready to use Goat Anti-Rabbit IgG H&L (HRP). Positive staining in apical surface of epithelial cells of human colon (PMID : 27027293) is observed. Counterstained with Hematoxylin

Secondary antibody only control : Used PBS instead of primary antibody, secondary antibody is a ready to use Goat Anti-Rabbit IgG H&L (HRP).

This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab270397).

IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] - BSA and Azide free (AB270402)

Immunohistochemical analysis of paraffin-embedded Human liver tissue labeling UNQ511 with ab270397 at 1/250 dilution (2 μg/ml) followed by a ready to use Goat Anti-Rabbit IgG H&L (HRP).

Negative control : no staining in human liver (PMID : 27027293).

Counterstained with Hematoxylin. Heat mediated antigen retrieval using ab93684 (Tris/EDTA buffer, pH 9.0)

Secondary antibody only control : Used PBS instead of primary antibody, secondary antibody is a ready to use Goat Anti-Rabbit IgG H&L (HRP).

This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab270397).

Unconjugated

Anti-UNQ511 antibody [EPR23557-128]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR23557-128

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

ab270402 is the carrier-free version of ab270397.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar^® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar^® is a trademark of Fluidigm Canada Inc.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Do Not Freeze

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UNQ511 also known by alternative names is a protein that actively participates in cellular signaling processes. It exhibits a molecular mass of approximately 55 kDa. Researchers observe its expression in several tissues with particular focus on tissues with high metabolic activity. Its mechanical function includes engaging in signaling pathways providing vital communication links within and between cells contributing to the regulation of cellular responses to environmental stimuli.

Biological function summary

UNQ511 contributes to cellular homeostasis and energy metabolism within the cell. It forms interactions with several other proteins suggesting that it acts as part of a protein complex. This protein complex plays an important role in maintaining energy balance and regulating cellular growth processes. The presence of UNQ511 within these complexes allows it to influence critical cellular functions necessary for maintaining healthy cell cycles.

Pathways

UNQ511 is integrated into metabolic and intracellular signaling pathways. It closely interacts within the AMP-activated protein kinase (AMPK) pathway which is essential for cellular energy homeostasis. Additionally it associates with proteins like AMPK which links it to key cellular energy sensors indicating its role in energy regulation and metabolism. The interplay of UNQ511 within these pathways highlights its importance in energy balance and response to cellular stress.

Scientific studies associate UNQ511 with metabolic disorders and certain types of cancer. Its interaction with AMPK and other metabolic regulators ties it to metabolic syndrome a condition involving dysregulated glucose metabolism. Furthermore alterations in its expression or function may contribute to cancer progression linking it to proteins known for oncogenic pathways. Understanding its role in these diseases could lead to the development of therapeutic interventions targeting these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.

See full target information LYPD8

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-UNQ511 antibody [EPR23557-128] - BSA and Azide free

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] - BSA and Azide free (AB270402)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UNQ511 antibody [EPR23557-128] - BSA and Azide free (AB270402)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Product promise