Rabbit Polyclonal Unrip antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STRAP aa 1-300.
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- Frontiers in molecular biosciences 7:552020The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDelphine Sapaly et. al.PubMed 32363199
- Cancer chemotherapy and pharmacology 82:1039-10472018Oncogenic roles of serine-threonine kinase receptor-associated protein (STRAP) in osteosarcoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDumnoensun Pruksakorn et. al.PubMed 30276452
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human STRAP aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y3F4
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Cow | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
Alternative names
MAWD, UNRIP, STRAP, Serine-threonine kinase receptor-associated protein, MAP activator with WD repeats, UNR-interacting protein, WD-40 repeat protein PT-WD
Recommended products
Rabbit Polyclonal Unrip antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STRAP aa 1-300.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human STRAP aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y3F4
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Unrip also known as NRIP (nuclear receptor interaction protein) is a nuclear protein with a molecular mass of approximately 64 kDa. Researchers have identified its expression mainly in the nucleus across various tissues. Mechanically Unrip functions as a factor interacting with nuclear hormone receptors. It regulates transcriptional activity through direct contact with these receptors modulating gene expression. This interaction plays a role in how cells respond to specific hormones and signals.
- Biological function summary
Unrip contributes significantly to the regulation of gene expression by associating with other nuclear coregulators. It is part of a larger protein complex that includes importin beta and RIC1/RAB1. This complex facilitates the proper localization and functioning of nuclear hormone receptors affecting the expression of target genes. Unrip’s involvement with such complexes illustrates its integral function in transcriptional regulation and cellular signaling pathways.
- Pathways
Unrip integrates into essential signaling networks particularly the nuclear receptor signaling and coactivator pathways. In these pathways Unrip modulates the activity of nuclear receptors like estrogen receptor alpha and glucocorticoid receptor affecting cellular responses to steroid hormones. Unrip interacts with proteins such as SRC-1 and GRIP1 within these pathways influencing gene expression profiles related to growth differentiation and metabolic processes.
- Associated diseases and disorders
Unrip’s interactions impact conditions including cancer and hormone-related disorders. Its role in modulating estrogen and glucocorticoid receptors links it to breast cancer progression where these pathways are dysregulated. Additionally Unrip’s involvement in nuclear receptor signaling ties it to metabolic disorders like type 2 diabetes. Through the alteration of receptor pathways Unrip affects proteins like PPARγ demonstrating its relevance in disease mechanisms and therapeutic research.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Unrip antibody (ab102001)
10% SDS PAGE
All lanes: Western blot - Anti-Unrip antibody (ab102001) at 1/2000 dilution
All lanes: HepG2 whole cell lysate at 30 µg
Predicted band size: 35 kDa, 38 kDa
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