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AB153861

Anti-UPP2 antibody

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(2 Publications)

Rabbit Polyclonal UPP2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Uridine phosphorylase 2 aa 1-250.

View Alternative Names

Uridine phosphorylase 2, UPase 2, UrdPase 2, UPP2

1 Images
Western blot - Anti-UPP2 antibody (AB153861)
  • WB

Unknown

Western blot - Anti-UPP2 antibody (AB153861)

10% SDS PAGE

All lanes:

Western blot - Anti-UPP2 antibody (ab153861) at 1/3000 dilution

Lane 1:

293T whole cell lysate at 30 µg

Lane 2:

A431 whole cell lysate at 30 µg

Lane 3:

HeLa whole cell lysate at 30 µg

Predicted band size: 36 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human Uridine phosphorylase 2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

O95045

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The UPP2 protein also known as Uridine Phosphorylase 2 catalyzes the reversible phosphorolysis of uridine to uracil and ribose 1-phosphate. It plays a pivotal role in nucleotide metabolism. The molecular mass of UPP2 is approximately 34 kDa. The protein expresses mainly in the liver and kidney where nucleoside metabolism is highly active indicating its significant involvement in regulating nucleoside homeostasis.
Biological function summary

This enzyme contributes to the salvage pathways of pyrimidine metabolism ensuring efficient recycling of nucleotides. It does not function alone; rather UPP2 can interact with other enzymes involved in nucleotide and nucleoside interconversions. It participates indirectly in pathways that manage nucleic acid degradation and synthesis essential for balancing cellular nucleotide pools.

Pathways

UPP2 plays a role in pyrimidine salvage and catabolic pathways. It involves itself in the conversion processes within these pathways influencing DNA and RNA turnover. The protein aligns closely with enzymes such as uridine phosphorylase 1 (UPP1) which also partake in similar reactions emphasizing their cooperation in maintaining nucleotide balance.

Abnormalities in UPP2 function have implications in cancer and metabolic disorders. Altered expression or activity of UPP2 links to cancerous proliferation through its effect on nucleotide availability. Additionally disruptions in uridine metabolism could relate to certain metabolic syndromes. The interaction between UPP2 and uridine phosphorylase 1 further demonstrates their joint involvement in these conditions highlighting potential targets for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed : 12849978, PubMed : 21855639). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (PubMed : 12849978).
See full target information Uridine phosphorylase 2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature metabolism 5:765-776 PubMed37198474

2023

Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Owen S Skinner,Joan Blanco-Fernández,Russell P Goodman,Akinori Kawakami,Hongying Shen,Lajos V Kemény,Lena Joesch-Cohen,Matthew G Rees,Jennifer A Roth,David E Fisher,Vamsi K Mootha,Alexis A Jourdain

Redox biology 58:102544 PubMed36427397

2022

CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Tian,Yunxin Lu,Jinfei Lin,Miao Chen,Huijuan Qiu,Wancui Zhu,Haohui Sun,Jinsheng Huang,Han Yang,Wuguo Deng
View all publications
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Product promise

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