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AB279379

Anti-Upstream Binding Protein 1 antibody [OTI9G7]

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Mouse Monoclonal Upstream Binding Protein 1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human UBP1 aa 1-300.

View Alternative Names

LBP1, UBP1, Upstream-binding protein 1, Transcription factor LBP-1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Upstream Binding Protein 1 antibody [OTI9G7] (AB279379)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Upstream Binding Protein 1 antibody [OTI9G7] (AB279379)

Paraffin embedded adenocarcinoma of human endometrium tissue stained for UBP1 using ab279379 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH 8.5, 120°C for 3 minutes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Upstream Binding Protein 1 antibody [OTI9G7] (AB279379)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Upstream Binding Protein 1 antibody [OTI9G7] (AB279379)

Paraffin embedded adenocarcinoma of human breast tissue stained for UBP1 using ab279379 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH 8.5, 120°C for 3 minutes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Upstream Binding Protein 1 antibody [OTI9G7] (AB279379)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Upstream Binding Protein 1 antibody [OTI9G7] (AB279379)

Paraffin embedded of human thyroid tissue stained for UBP1 using ab279379 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH 8.5, 120°C for 3 minutes.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI9G7

Isotype

IgG2a

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human UBP1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q9NZI7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Upstream Binding Protein 1 (UBP1) also known as HNF4α-stimulating factor (HSF) acts as a transcription factor involved in the regulation of gene expression. With a molecular weight of about 67 kDa UBP1 recognizes and binds to specific DNA sequences in the promoter regions of various genes mediating the transcription process. It is expressed in several tissues including the liver and heart where it plays a critical role in modulating the activity of target genes involved in metabolic and developmental pathways.
Biological function summary

UBP1 is important for facilitating RNA polymerase II-driven transcription by aiding in the formation of transcription complexes. It contributes to chromatin remodeling which promotes gene expression changes necessary for cellular functions. UBP1 interacts as part of larger multi-protein complexes recruiting other transcription factors and co-regulators to enhance or repress gene expression which directly impacts cellular growth and differentiation processes.

Pathways

UBP1 interacts within the Wnt signaling and PI3K-Akt pathways both of which are essential for regulating cell proliferation differentiation and survival. In the Wnt pathway UBP1 modulates the expression of genes required for normal cellular communication and fate determination. It also interacts with proteins such as β-catenin in the Wnt pathway and serves as a convergence point with other transcription factors influencing the expression of genes involved in cell cycle regulation and apoptosis.

UBP1 has a connection to metabolic syndromes like non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases. Dysregulation of UBP1 leads to abnormal expression of genes that contribute to lipid and glucose metabolism linking it closely to metabolic imbalances observed in NAFLD. Additionally altered interactions between UBP1 and transcription regulators like PPARα can intensify inflammatory responses and oxidative stress exacerbating cardiovascular disease conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
See full target information UBP1
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Product promise

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For full details, please see our Terms & Conditions

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