JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB210612

Anti-Urocortin 3 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Urocortin 3 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human UCN3 aa 100 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

SPC, UCN3, Urocortin-3, Stresscopin, Urocortin III, Ucn III

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Urocortin 3 antibody (AB210612)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Urocortin 3 antibody (AB210612)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat kidney tissue labeling Urocortin 3 with ab210612 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human UCN3 aa 100 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q969E3

style
left-column

Complementary Products

Primary Antibodies

AB92517

Anti-Glucagon antibody [EP3070]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [EP3070] (AB92517)

  • 5
  • 8
Primary Antibodies

AB184238

Anti-CRF antibody [EPR19154]

RabMAb|Recombinant

Western blot - Anti-CRF antibody [EPR19154] (AB184238)

  • 5
  • 1
Primary Antibodies

AB214321

Anti-RASAL1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RASAL1 antibody (AB214321)

  • 0
  • 0
Primary Antibodies

AB233757

Anti-IL-9R antibody [4A11H2]

Western blot - Anti-IL-9R antibody [4A11H2] (AB233757)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Urocortin 3 also known as Stresscopin is a peptide with a mass of approximately 5 kDa belonging to the corticotropin-releasing factor (CRF) family. It operates mechanically by binding to specific receptors primarily CRF2 receptors to exert physiological effects. Researchers have observed expression of Urocortin 3 primarily in the hypothalamus and certain peripheral tissues like the adrenal glands and the gastrointestinal tract. This peptide plays a significant role in influencing stress-related responses through these receptor interactions.
Biological function summary

This peptide is involved in modulating stress behavior and homeostasis. By activating CRF2 receptors it plays a role in reducing anxiety and stress contrasting with other CRF family proteins that typically increase stress responses. Urocortin 3 does not exist as a simple isolated protein but interacts as part of a complex signaling network affecting neuroendocrine functions. Its distribution and receptor preference help it to mediate effects distinct from other CRF family members providing a counterbalance in biological stress responses.

Pathways

Urocortin 3 affects the hypothalamic-pituitary-adrenal (HPA) axis and the cardiovascular system. In the HPA axis it regulates the secretion of adrenocorticotropic hormone (ACTH) and modulates cortisol release impacting overall stress hormone levels. Relative proteins in these pathways include CRF1 and CRF2 which enliven different aspects of stress and anxiety regulation. In the cardiovascular system Urocortin 3 has been linked to vasodilation and blood pressure regulation.

Urocortin 3's modulation of stress responses ties it to conditions like anxiety disorders and heart disease. In anxiety disorders its role as an anxiolytic contrasts with CRF1 receptor pathways often linked to heightened stress. It's important in maintaining balanced stress responses through CRF2 pathways. In heart disease researchers study its vasodilatory properties for potential therapeutic benefits associating its effects with the regulation of blood pressure and cardiac stress protection in relation to its interaction with CRF2 receptors.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
See full target information UCN3
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2303946 PubMed37897313

2023

Impaired Efferocytosis Enables Apoptotic Osteoblasts to Escape Osteoimmune Surveillance During Aging.

Applications

Unspecified application

Species

Unspecified reactive species

Rongyao Xu,Hanyu Xie,Xin Shen,Jiadong Huang,Hengguo Zhang,Yu Fu,Ping Zhang,Songsong Guo,Dongmiao Wang,Sheng Li,Kai Zheng,Wen Sun,Laikui Liu,Jie Cheng,Hongbing Jiang
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com