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AB58459

Anti-Urocortin antibody

5

(2 Reviews)

|

(3 Publications)

Rabbit Polyclonal Urocortin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Urocortin.

View Alternative Names

Urocortin, UCN

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Urocortin antibody (AB58459)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Urocortin antibody (AB58459)

ab58459 at 1/50-1/100 dilution staining human lung carcinoma without and with blocking peptide; paraffin embedded.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Urocortin. The exact immunogen used to generate this antibody is proprietary information.

P55089

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Urocortin also known as UCN is a member of the corticotropin-releasing factor (CRF) family of peptides with a molecular weight of approximately 4.7 kDa. It engages in binding to CRF receptors especially CRF-R2 promoting a range of effects in different tissues. Urocortin is expressed in numerous brain regions including the hypothalamus and Edinger-Westphal nucleus as well as in peripheral tissues like the gastrointestinal tract and heart.
Biological function summary

This peptide hormone is involved in stress response and regulation of food intake. Urocortin modulates the activity of neuronal systems contributing to various physiological functions including cardiovascular homeostasis. It does not work as part of a complex but exerts its effects through receptor-ligand interactions predominantly with CRF-R2 influencing vasodilation and reducing anxiety-like behaviors.

Pathways

Urocortin exerts its biological roles through the corticotropin-releasing hormone signaling pathway. This pathway is fundamental in the body's response to stress. Urocortin's interaction with CRF-R2 links it to other CRF-related peptides such as CRF itself and Urocortin II in regulating stress-related responses and energy homeostasis via these pathways.

Research indicates Urocortin's involvement in heart failure and anxiety disorders. In heart failure Urocortin's role in cardiovascular function places it alongside proteins such as atrial natriuretic peptide (ANP) in maintaining heart health. Moreover in anxiety disorders it shares connections with CRF in modulating behavioral responses to stress pointing to potential therapeutic applications in treating stress-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed : 8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed : 8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).
See full target information Urocortin
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer gene therapy 30:567-574 PubMed35338347

2022

SUMOylation inhibition enhances multiple myeloma sensitivity to lenalidomide.

Applications

Unspecified application

Species

Unspecified reactive species

Li Du,Wei Liu,Flavia Pichiorri,Steven T Rosen

Postepy dermatologii i alergologii 38:461-472 PubMed34377129

2021

Modulation of dermal equivalent of hypothalamus-pituitary-adrenal axis in mastocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jakub Antoniewicz,Bogusław Nedoszytko,Magdalena Lange,Justyna Wierzbicka,Magdalena Górska-Ponikowska,Marek Niedoszytko,Monika Zabłotna,Roman J Nowicki,Michał A Żmijewski

Journal of cellular physiology 232:154-66 PubMed27061711

2016

Differentiation of Keratinocytes Modulates Skin HPA Analog.

Applications

Unspecified application

Species

Unspecified reactive species

Justyna M Wierzbicka,Michał A Żmijewski,Jakub Antoniewicz,Michal Sobjanek,Andrzej T Slominski
View all publications
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Product promise

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