Anti-Uroplakin II/UPII antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Uroplakin II functions as part of the larger uroplakin protein complex. UPII interacts with other uroplakins such as Uroplakin Ia Ib and III contributing to the formation of a multimeric structure that strengthens the urothelial cells' surface. This structure plays a role in cellular stabilization and preventing the passage of toxic substances and pathogens from the urine into the underlying tissue. Consequently it aids in maintaining tissue integrity and ensuring efficient functioning of the urinary system.

Pathways

The uroplakin complex integrates into the pathway of epithelial differentiation. Uroplakin II's association with other uroplakins influences the formation of the AUM which involves the coordinated action of several related proteins such as claudins. The interaction with claudins suggests a potential regulatory role for cell-cell adhesion within epithelial transport pathways. This role might interact with tight junction pathways that are important for maintaining the selective permeability of epithelial layers.