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AB194676

Anti-Urotensin II antibody - C-terminal

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(4 Publications)

Rabbit Polyclonal Urotensin II antibody. C-terminal. Suitable for WB and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human UTS2 aa 1 to C-terminus.

View Alternative Names

UNQ525/PRO1068, UTS2, Urotensin-2, Urotensin II, U-II, UII

1 Images
Western blot - Anti-Urotensin II antibody - C-terminal (AB194676)
  • WB

Supplier Data

Western blot - Anti-Urotensin II antibody - C-terminal (AB194676)

All lanes:

Western blot - Anti-Urotensin II antibody - C-terminal (ab194676) at 1/500 dilution

Lane 1:

Mouse skeletal muscle lysate

Lane 2:

Mouse testis lysate

Lane 3:

Mouse liver lysate

Predicted band size: 14 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human UTS2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O95399

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Urotensin II sometimes referred to as UII is a cyclic peptide with a molecular mass of around 1.6 kDa. It is found in the central nervous system as well as peripheral tissues including the heart kidneys and lungs. The peptide interacts with the G-protein-coupled receptor known as UT receptor or UTS2R. This interaction initiates downstream signaling processes. Urotensin II is secreted by endothelial cells and influences smooth muscle contraction.
Biological function summary

Urotensin II impacts cardiovascular and renal systems through its regulation of vascular tone and blood pressure. It acts independently and is not part of a larger molecular complex. Its influence on these systems points to its role in fluid homeostasis and vascular modulation. Urotensin II serves as a potent vasoconstrictor especially in the human thoracic arteries and also modulates cardiac function.

Pathways

Many cardiovascular- and renal-related signaling cascades include Urotensin II. For instance interaction with the UT receptor activates the phospholipase C (PLC) pathway which involves proteins like inositol trisphosphate and diacylglycerol. Its vasoconstrictive action aligns with the endothelin pathway where it operates in coordination with endothelin-1 suggesting a complementary function in blood vessel modulation and maintenance.

Dysfunction of Urotensin II signaling appears in conditions like hypertension and heart failure. Its regulation of vascular tone implicates it in hypertensive states where altered expression or receptor interaction can exacerbate high blood pressure. In heart failure Urotensin II levels rise in response to increased cardiac strain linking it to the pathophysiology of cardiac remodeling. Research indicates that it might interact with proteins like angiotensin II amplifying its role in the progression of these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Highly potent vasoconstrictor.
See full target information UTS2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Kidney & blood pressure research 44:479-495 PubMed31238319

2019

Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure.

Applications

Unspecified application

Species

Unspecified reactive species

Ya-Jing Pan,Si-Jia Zhou,Jin Feng,Qiong Bai,La-Ta A,Ai-Hua Zhang

Oncology reports 36:2800-2806 PubMed27600191

2016

UII/GPR14 is involved in NF-κB-mediated colonic inflammation in vivo and in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Yang,Jinpei Zhang,Xi Chen,Tao Wu,Xin Xu,Gang Cao,Hua Li,Yiming Li

Journal of diabetes investigation 8:629 PubMed27459313

2016

Retraction statement: ‘Urotensin II inhibits autophagy in renal tubular epithelial cells and induces extracellular matrix production in early diabetic mice’ by Guan‐Jong Chen, Fei Wu, Xin‐Xin Pang, Ai‐Hua Zhang, Jun‐Bao Shi, Min Lu and Chao‐Shu Tang

Applications

Unspecified application

Species

Unspecified reactive species

Guan-Jong Chen,Fei Wu,Xin-Xin Pang,Ai-Hua Zhang,Jun-Bao Shi,Min Lu,Chao-Shu Tang

Kidney & blood pressure research 41:434-49 PubMed27467277

2016

Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xin-Xin Pang,Qiong Bai,Fei Wu,Guan-Jong Chen,Ai-Hua Zhang,Chao-Shu Tang
View all publications
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