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AB82714

Anti-USH2A antibody

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(1 Publication)

Rabbit Polyclonal USH2A antibody. Suitable for ELISA and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Usherin, Usher syndrome type IIa protein, Usher syndrome type-2A protein, USH2A

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 24/11/2017. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

USH2A also known as Usherin is a protein encoded by the USH2A gene. This protein has a mass of approximately 610 kDa. It is a large transmembrane protein found mainly in the retina and the inner ear. USH2A contains several modules including laminin EGF-like fibronectin type III and laminin G domains which contribute to its role in cellular adhesion and signal transduction. The protein localizes on the photoreceptor cells in the eye and plays a role in maintaining their structure.
Biological function summary

USH2A supports the structural integrity and function of photoreceptors and hair cells. It is not part of a known complex but interacts closely with other proteins in the extracellular matrix. The protein helps stabilize the connections between cells by interacting with cell-surface receptors. This interaction supports proper sensory perception by maintaining cell ellipsoid zones in the retina and stereocilia in the ear.

Pathways

The protein interacts within the Usher syndrome pathway and the visual cycle pathway. In these pathways it is closely related to other Usher syndrome-associated proteins such as ADGRV1 and WHRN. These proteins form networks that are essential for the maintenance of photoreceptor cells and sensory hair cells. USH2A contributes to the complex processes that are necessary for both vision and hearing.

USH2A mutations are linked to Usher syndrome type II and retinitis pigmentosa. Usher syndrome type II leads to moderate hearing loss and progressive vision loss while retinitis pigmentosa results in the degeneration of the retina. In these disorders other proteins such as MYO7A and CDH23 are also implicated but USH2A mutations have been identified as significant contributors especially to the degradation and dysfunction of sensory cells in the affected tissues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.
See full target information USH2A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of reproduction and development 68:198-208 PubMed35228412

2022

Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Syuan Wei,Wan-Zhen Lin,Tse-En Wang,Wei-Yun Lee,Sheng-Hsiang Li,Fu-Jung Lin,Brett Nixon,Petra Sipilä,Pei-Shiue Tsai
View all publications
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Product promise

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