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AB102470

Anti-USO1 antibody

5

(7 Reviews)

|

(3 Publications)

Rabbit Polyclonal USO1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USO1 aa 1-200.

View Alternative Names

VDP, USO1, General vesicular transport factor p115, Protein USO1 homolog, Transcytosis-associated protein, Vesicle-docking protein, TAP

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USO1 antibody (AB102470)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USO1 antibody (AB102470)

ab102470 at 1/500 dilution staining USO1 in Human lung carcinoma by Immunohistochemistry, Paraffin-embedded tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human USO1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

O60763

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Alternative Products

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10mM Citrate buffer or Tris-EDTA buffer (pH 8.0).</p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

USO1 also known as p115 is a heavy protein weighing approximately 112 kDa. It functions as a general vesicle tethering factor critical for the fusion of Golgi-derived vesicles. USO1 operates by binding to both vesicle and target membranes facilitating vesicular trafficking within the Golgi apparatus. It expresses broadly across various cell types underpinning its essential role in intracellular transport processes.
Biological function summary

The USO1 protein plays an instrumental role in maintaining Golgi structure and function. It belongs to the transport protein particle (TRAPP) complex and works closely with several other proteins in the vesicle tethering and fusion steps. By interacting with the Golgi SNAREs USO1 helps mediate the fusion process necessary for protein and lipid transport.

Pathways

USO1 integrates into cellular trafficking and transport pathways. It participates in the Golgi transport pathway working alongside proteins like GM130 and NSF to ensure stabilized vesicle docking and fusion. USO1's function connects it to the secretory pathway where it assists in uniting the endoplasmic reticulum's production line with the Golgi's packaging and shipping center.

Abnormalities in USO1 function associate with neurological disorders and cancer progressions. USO1's interaction with GM130 links its dysfunctional activity to neuronal migration defects. Additionally aberrations in USO1 levels can influence cancer cell proliferation denoting its potential as a target for therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
See full target information USO1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of proteomics 229:103926 PubMed32736139

2020

Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Progga Sen,Chin Fung Kelvin Kan,Amar B Singh,Monica Rius,Fredric B Kraemer,Elizabeth Sztul,Jingwen Liu

Frontiers in bioengineering and biotechnology 8:456 PubMed32500067

2020

Optimisation of a Novel Bio-Substrate as a Treatment for Atrophic Age-Related Macular Degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel McCormick,Ian Pearce,Stephen Kaye,Atikah Haneef

Oncogene 37:1308-1325 PubMed29249802

2017

A CREB3-regulated ER-Golgi trafficking signature promotes metastatic progression in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Breege V Howley,Laura A Link,Simon Grelet,Maya El-Sabban,Philip H Howe
View all publications
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Product promise

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