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AB167059

Anti-USP19 antibody

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(1 Publication)

Rabbit Polyclonal USP19 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human USP19.

View Alternative Names

KIAA0891, ZMYND9, USP19, Ubiquitin carboxyl-terminal hydrolase 19, Deubiquitinating enzyme 19, Ubiquitin thioesterase 19, Ubiquitin-specific-processing protease 19, Zinc finger MYND domain-containing protein 9

2 Images
Western blot - Anti-USP19 antibody (AB167059)
  • WB

Unknown

Western blot - Anti-USP19 antibody (AB167059)

All lanes:

Western blot - Anti-USP19 antibody (ab167059) at 1/500 dilution

Lane 1:

NIH3T3 cell extract

Lane 2:

NIH3T3 cell extract with immunizing peptide

Predicted band size: 146 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USP19 antibody (AB167059)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USP19 antibody (AB167059)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling USP19 with ab167059 at 5 µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human USP19. The exact immunogen used to generate this antibody is proprietary information.

O94966

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

USP19 also known as Ubiquitin Specific Peptidase 19 is an enzyme with deubiquitinating activity. It belongs to the family of cysteine proteases and has a molecular mass of approximately 150 kDa. This protein's primary function involves the removal of ubiquitin from specific protein substrates regulating their degradation and maintaining protein homeostasis. USP19 is expressed in multiple tissues including skeletal muscle heart and brain indicating its widespread physiological roles.
Biological function summary

The regulation of protein turnover and cellular stress responses involves USP19. As a standalone enzyme it participates independently rather than as part of a larger protein complex. By deubiquitinating target proteins USP19 influences their stability and function affecting a variety of cellular processes such as protein synthesis cell cycle progression and stress response through modulation of ubiquitin chains on substrates.

Pathways

The modulation of protein degradative pathways involves USP19 specifically impacting the ubiquitin-proteasome system (UPS) and chaperone-mediated autophagy (CMA). It interacts with key proteins in these pathways such as ubiquitin-conjugating enzymes and proteasomal subunits to maintain cellular homeostasis. By regulating pathways like UPS USP19 plays a role in controlling protein quality and preventing aggregation which is critical for cell function.

The dysregulation of protein degradation mechanisms implicates USP19 in conditions such as muscle atrophy and neurodegenerative diseases. Abnormal activity of USP19 associates with disorders like Parkinson’s disease where it may interact with proteins such as Parkin affecting the ubiquitination balance. Studies on USP19 continue to explore its potential as a therapeutic target for treating these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains.
See full target information USP19
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oxidative medicine and cellular longevity 2021:8880141 PubMed33628391

2021

The Protective Effect of Cyanidin-3-Glucoside on Myocardial Ischemia-Reperfusion Injury through Ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Shan,Zhi-Yang Lv,Meng-Jiao Yin,Jing Chen,Jie Wang,Qi-Nan Wu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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