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AB93159

Anti-USP19 antibody

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(6 Publications)

Rabbit Polyclonal USP19 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human USP19.

View Alternative Names

KIAA0891, ZMYND9, USP19, Ubiquitin carboxyl-terminal hydrolase 19, Deubiquitinating enzyme 19, Ubiquitin thioesterase 19, Ubiquitin-specific-processing protease 19, Zinc finger MYND domain-containing protein 9

2 Images
Western blot - Anti-USP19 antibody (AB93159)
  • WB

Unknown

Western blot - Anti-USP19 antibody (AB93159)

Western blot analysis of extracts from 3T3 cells, using ab93159 antibody

All lanes:

Western blot - Anti-USP19 antibody (ab93159)

Predicted band size: 146 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USP19 antibody (AB93159)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USP19 antibody (AB93159)

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ab93159

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human USP19. The exact immunogen used to generate this antibody is proprietary information.

O94966

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50.00000 - 1/100.00000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500.00000 - 1/1000.00000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

USP19 also known as Ubiquitin Specific Peptidase 19 is an enzyme with deubiquitinating activity. It belongs to the family of cysteine proteases and has a molecular mass of approximately 150 kDa. This protein's primary function involves the removal of ubiquitin from specific protein substrates regulating their degradation and maintaining protein homeostasis. USP19 is expressed in multiple tissues including skeletal muscle heart and brain indicating its widespread physiological roles.
Biological function summary

The regulation of protein turnover and cellular stress responses involves USP19. As a standalone enzyme it participates independently rather than as part of a larger protein complex. By deubiquitinating target proteins USP19 influences their stability and function affecting a variety of cellular processes such as protein synthesis cell cycle progression and stress response through modulation of ubiquitin chains on substrates.

Pathways

The modulation of protein degradative pathways involves USP19 specifically impacting the ubiquitin-proteasome system (UPS) and chaperone-mediated autophagy (CMA). It interacts with key proteins in these pathways such as ubiquitin-conjugating enzymes and proteasomal subunits to maintain cellular homeostasis. By regulating pathways like UPS USP19 plays a role in controlling protein quality and preventing aggregation which is critical for cell function.

The dysregulation of protein degradation mechanisms implicates USP19 in conditions such as muscle atrophy and neurodegenerative diseases. Abnormal activity of USP19 associates with disorders like Parkinson’s disease where it may interact with proteins such as Parkin affecting the ubiquitination balance. Studies on USP19 continue to explore its potential as a therapeutic target for treating these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains.
See full target information USP19
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Autophagy 18:891-908 PubMed34436957

2021

USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Xibao Zhao,Qianqian Di,Juan Yu,Jiazheng Quan,Yue Xiao,Huihui Zhu,Hongrui Li,Jing Ling,Weilin Chen

Oncology reports 43:1964-1974 PubMed32236633

2020

Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenbing Hu,Yanfang Su,Xinxiong Fei,Xudong Wang,Guanglin Zhang,Chunyan Su,Tianxing Du,Tao Yang,Gangsheng Wang,Ze Tang,Jierong Zhang

Nature communications 10:4115 PubMed31511519

2019

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Wu,Caoqi Lei,Tian Xia,Xuan Zhong,Qing Yang,Hong-Bing Shu

Journal of immunology (Baltimore, Md. : 1950) 203:259-268 PubMed31127032

2019

USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.

Applications

Unspecified application

Species

Unspecified reactive species

Cao-Qi Lei,Xin Wu,Xuan Zhong,Lu Jiang,Bo Zhong,Hong-Bing Shu

Scientific reports 9:951 PubMed30700749

2019

USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth.

Applications

Unspecified application

Species

Unspecified reactive species

Maria E Gierisch,Gloria Pedot,Franziska Walser,Laura A Lopez-Garcia,Patricia Jaaks,Felix K Niggli,Beat W Schäfer

The Journal of biological chemistry 286:41455-65 PubMed21971047

2011

17β-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α.

Applications

WB

Species

Mouse

Masahiro Ogawa,Ryoichi Yamaji,Yasuki Higashimura,Naoki Harada,Hitoshi Ashida,Yoshihisa Nakano,Hiroshi Inui
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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