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AB188239

Anti-USP26 antibody

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(1 Publication)

Rabbit Polyclonal USP26 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human USP26 aa 500-800.

View Alternative Names

Ubiquitin carboxyl-terminal hydrolase 26, Deubiquitinating enzyme 26, Ubiquitin thioesterase 26, Ubiquitin-specific-processing protease 26, USP26

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-USP26 antibody (AB188239)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-USP26 antibody (AB188239)

Immunofluorescent analysis of 3% PFA-fixed U2OS cells overexpressing DDDDK-tagged USP26, labeling USP26 (red) with ab188239 at 1/5000 dilution. Cells were also stained with an Anti-DDDDK tag antibody (green).

Western blot - Anti-USP26 antibody (AB188239)
  • WB

Supplier Data

Western blot - Anti-USP26 antibody (AB188239)

Western blot analysis (using ab188239 at a 1/2000 dilution) of immunoprecipitates using 293T cell extracts transfected or not with Flag-USP26

Lane 1 : Input of non-transfected 293 cells

Lane 2 : Input of transfected cells with Flag-USP26

Lane 3 : immunoprecipitate with control serum+protein A sepharose.

Lane 4 : immunoprecipitate with ab188239+ protein A sepharose.

All lanes:

Western blot - Anti-USP26 antibody (ab188239)

Predicted band size: 104 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human USP26 aa 500-800. The exact immunogen used to generate this antibody is proprietary information.

Q9BXU7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/5000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.05% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

USP26 also known as Ubiquitin Specific Peptidase 26 is an enzyme that removes ubiquitin moieties from specific proteins regulating their degradation localization or activity. USP26 is part of the deubiquitinating enzymes (DUBs) family and has a molecular mass of approximately 104 kDa. It expresses mainly in testicular tissue which indicates its role in reproductive biology.
Biological function summary

The enzyme plays a role in spermatogenesis the process of sperm cell development. It participates in the regulation of the androgen receptor (AR) signaling pathway. By interacting with receptors it stabilizes and modulates their activity contributing to normal testicular function. This connects USP26 to a protein complex involving androgen receptors which are essential for male reproductive health.

Pathways

The deubiquitinating activity of USP26 influences the androgen receptor signaling pathway important for male reproductive processes. In the ubiquitin-proteasome system USP26 modulates the stability of the AR receptor and other proteins related to this pathway which may include factors like HSP90 that aid in receptor activation and stabilization.

Anomalies in USP26 function correlate with male infertility. Mutations or altered expression are linked to disorders in spermatogenesis. This has connections with androgen receptor abnormalities as proper receptor function is necessary for normal sperm production. Studies also find indications that dysregulation may link to prostate cancer where androgen receptor involvement is critical.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes (PubMed : 20501646, PubMed : 28839133). Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1) (PubMed : 28839133). Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway (PubMed : 20501646). May play a role in spermatogenesis (PubMed : 34202084).
See full target information USP26
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer letters 448:52-60 PubMed30763716

2019

USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Li,Honghong Zhou,Rui Zhu,Zhihua Liu
View all publications
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Product promise

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