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AB230226

Anti-USP26 antibody

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(2 Publications)

Rabbit Polyclonal USP26 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USP26 aa 650 to C-terminus.

View Alternative Names

Ubiquitin carboxyl-terminal hydrolase 26, Deubiquitinating enzyme 26, Ubiquitin thioesterase 26, Ubiquitin-specific-processing protease 26, USP26

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USP26 antibody (AB230226)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USP26 antibody (AB230226)

Paraffin-embedded human small intestine tissue stained for USP26 using ab230226 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USP26 antibody (AB230226)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USP26 antibody (AB230226)

Paraffin-embedded human liver tissue stained for USP26 using ab230226 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-USP26 antibody (AB230226)
  • WB

Supplier Data

Western blot - Anti-USP26 antibody (AB230226)

All lanes:

Western blot - Anti-USP26 antibody (ab230226) at 1/1000 dilution

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate

Lane 2:

U937 (human histiocytic lymphoma cell line) whole cell lysate

Lane 3:

Mouse gonadal lysate

Lane 4:

Mouse liver lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 104 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human USP26 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BXU7

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Alternative Products

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Secondary Antibodies

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Androgen Receptor antibody [EPR1535(2)] (AB133273)

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Primary Antibodies

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Primary Antibodies

AB22552

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

USP26 also known as Ubiquitin Specific Peptidase 26 is an enzyme that removes ubiquitin moieties from specific proteins regulating their degradation localization or activity. USP26 is part of the deubiquitinating enzymes (DUBs) family and has a molecular mass of approximately 104 kDa. It expresses mainly in testicular tissue which indicates its role in reproductive biology.
Biological function summary

The enzyme plays a role in spermatogenesis the process of sperm cell development. It participates in the regulation of the androgen receptor (AR) signaling pathway. By interacting with receptors it stabilizes and modulates their activity contributing to normal testicular function. This connects USP26 to a protein complex involving androgen receptors which are essential for male reproductive health.

Pathways

The deubiquitinating activity of USP26 influences the androgen receptor signaling pathway important for male reproductive processes. In the ubiquitin-proteasome system USP26 modulates the stability of the AR receptor and other proteins related to this pathway which may include factors like HSP90 that aid in receptor activation and stabilization.

Anomalies in USP26 function correlate with male infertility. Mutations or altered expression are linked to disorders in spermatogenesis. This has connections with androgen receptor abnormalities as proper receptor function is necessary for normal sperm production. Studies also find indications that dysregulation may link to prostate cancer where androgen receptor involvement is critical.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes (PubMed : 20501646, PubMed : 28839133). Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1) (PubMed : 28839133). Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway (PubMed : 20501646). May play a role in spermatogenesis (PubMed : 34202084).
See full target information USP26
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:110954 PubMed39381753

2024

The prion protein is required for normal responses to light stimuli by photoreceptors and bipolar cells.

Applications

Unspecified application

Species

Unspecified reactive species

James F Striebel,James A Carroll,Brent Race,Jacqueline M Leung,Cindi Schwartz,Emily D Reese,Catherine Bowes Rickman,Bruce Chesebro,Mikael Klingeborn

Cell death and differentiation 29:1123-1136 PubMed35091692

2022

The osteoprotective role of USP26 in coordinating bone formation and resorption.

Applications

Unspecified application

Species

Unspecified reactive species

Changwei Li,Minglong Qiu,Leilei Chang,Jin Qi,Lianfang Zhang,Bernhard Ryffel,Lianfu Deng
View all publications
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Product promise

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