Anti-USP37 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

USP37 also known as Ubiquitin-Specific Protease 37 is an enzyme that functions as a deubiquitinase. Mechanically it removes ubiquitin from specific protein substrates therefore regulating their degradation by the proteasome. The protein has a mass of approximately 110 kDa. It expresses widely across various tissues with higher levels noticeable in testis brain and placenta which suggests a context-dependent role in different cell types.

Biological function summary

USP37 plays an important role in cell cycle regulation by stabilizing proteins that are key during this process. For example it stabilizes the cyclin A protein which is necessary for the transition between G1/S phases of the cell cycle. USP37 does not function alone; it interacts with other proteins and sometimes becomes part of complexes orchestrating both cellular growth and division by ensuring precise timing and progression within the cell cycle.

Pathways

USP37 is particularly integral to the cell cycle control and DNA damage response pathways. In the cell cycle pathway it closely interacts with Cyclin-dependent kinase 2 (CDK2) regulating transition checkpoints. In the DNA damage response pathway its interaction with proteins like ATR (ataxia telangiectasia and Rad3-related protein) helps maintain genomic integrity by modulating repair processes. These interactions illustrate how USP37 links mechanistic actions to larger functional pathways.

Associated diseases and disorders

USP37 has implications in oncogenesis and neurodegenerative diseases. Its deregulation may contribute to the development of cancers by affecting the stability of proteins involved in cell proliferation evident in some breast and prostate cancers. In neurodegenerative diseases like Alzheimer’s USP37’s interaction with the protein Tau may influence neurofibrillary tangle formation a hallmark of the disorder. Understanding these connections aids in researching potential therapeutic targets and interventions.