AB217304

Anti-Uteroglobin antibody

Name: Anti-Uteroglobin antibody (ab217304) | Abcam
Brand: Abcam Limited
SKU: AB217304

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(1 Publication)

Rabbit Polyclonal Uteroglobin antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Scgb1a1 aa 1 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Cc10, Ugb, Utg, Scgb1a1, Uteroglobin, Club cell phospholipid-binding protein, Club cells 10 kDa secretory protein, PCB-binding protein, Secretoglobin family 1A member 1, CCPBP, CC10

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uteroglobin antibody (AB217304)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uteroglobin antibody (AB217304)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat lung tissue labeling Uteroglobin with ab217304 at 1/100 dilution followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Mouse Scgb1a1 aa 1 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q06318

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Uteroglobin also known as Clara cell secretory protein (CC16) is a small secreted protein with a molecular mass of approximately 16 kDa. Expressed chiefly in the respiratory epithelium of the lungs particularly by Clara cells it is also present in other tissues such as the kidney and uterus. Uteroglobin acts as an anti-inflammatory and immunomodulatory protein playing an important role in protecting epithelial cells from damage by various harmful agents.

Biological function summary

Uteroglobin serves as a multifunctional secretory agent contributing to the regulation of inflammation and tissue remodeling. It does not form part of a larger complex but acts independently. By binding and inhibiting pro-inflammatory mediators like phospholipase A2 Uteroglobin reduces the production of arachidonic acid derivatives which are involved in inflammatory processes. Additionally it acts as a chemoattractant for certain immune cells further modulating immune responses.

Pathways

Uteroglobin integrates into the immune response and inflammation pathways. It indirectly interacts with proteins such as cytokines and chemokines influencing pathways like the arachidonic acid metabolism pathway and the leukocyte extravasation signaling pathway. These interactions reduce inflammatory response and regulate immune cell movement demonstrating its anti-inflammatory function.

Low levels of Uteroglobin have been associated with respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). By affecting inflammation pathways Uteroglobin interacts with inflammatory cytokines which exacerbate these conditions. Additionally its connection to proteins involved in these pathways makes it a potential biomarker for assessing lung injury and monitoring disease progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

See full target information Scgb1a1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell stress & chaperones 26:433-441 PubMed33471265

2021

Effect of Nrf2 signaling pathway on the improvement of intestinal epithelial barrier dysfunction by hyperbaric oxygen treatment after spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xuehua Liu,Fang Liang,Wei Song,Xiaoli Diao,Wanqiu Zhu,Jing Yang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Uteroglobin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uteroglobin antibody (AB217304)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Secondary Antibodies

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Primary Antibodies

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise