AB40873

Anti-Uteroglobin antibody

Name: Anti-Uteroglobin antibody. Rabbit polyclonal (ab40873) | Abcam
Brand: Abcam Limited
SKU: AB40873
Price: 500 USD
Availability: InStock
Rating: 4 (6 reviews)

(6 Reviews)

(54 Publications)

Rabbit Polyclonal Uteroglobin antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 54 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Scgb1a1.

View Alternative Names

Cc10, Ugb, Utg, Scgb1a1, Uteroglobin, Club cell phospholipid-binding protein, Club cells 10 kDa secretory protein, PCB-binding protein, Secretoglobin family 1A member 1, CCPBP, CC10

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uteroglobin antibody (AB40873)

IHC-P

AbReview23011****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uteroglobin antibody (AB40873)

ab40873 staining Uteroglobin in human lung parenchyma tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Tissue was fixed with formaldehyde and a heat mediated antigen retrieval step was performed using 10mM citrate buffer. Samples were then blocked with 1% BSA, 0.1% Triton-X/ PBS for 15 minutes at 18°C followed by incubation with the primary antibody at a 1/500 dilution for 16 hours at 4°C. An HRP-conjugated pig anti-rabbit polyclonal was used as secondary antibody at a 1/100 dilution.

Image courtesy of an anonymous Abreview.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uteroglobin antibody (AB40873)

Adult mouse lung was embedded in paraffin and stained with ab40873 (1 : 1600 dilution).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Rat Scgb1a1.

P17559

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1600", "IHCP-species-notes": "<p></p>" } } }

style

left-column

Product details

This antibody is useful for distinguishing ciliated from non-ciliated cells in the adult mouse lung.

style

left-column

Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Preservative: 0.01% Sodium azide Constituents: Whole serum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Uteroglobin also known as Clara cell secretory protein (CC16) is a small secreted protein with a molecular mass of approximately 16 kDa. Expressed chiefly in the respiratory epithelium of the lungs particularly by Clara cells it is also present in other tissues such as the kidney and uterus. Uteroglobin acts as an anti-inflammatory and immunomodulatory protein playing an important role in protecting epithelial cells from damage by various harmful agents.

Biological function summary

Uteroglobin serves as a multifunctional secretory agent contributing to the regulation of inflammation and tissue remodeling. It does not form part of a larger complex but acts independently. By binding and inhibiting pro-inflammatory mediators like phospholipase A2 Uteroglobin reduces the production of arachidonic acid derivatives which are involved in inflammatory processes. Additionally it acts as a chemoattractant for certain immune cells further modulating immune responses.

Pathways

Uteroglobin integrates into the immune response and inflammation pathways. It indirectly interacts with proteins such as cytokines and chemokines influencing pathways like the arachidonic acid metabolism pathway and the leukocyte extravasation signaling pathway. These interactions reduce inflammatory response and regulate immune cell movement demonstrating its anti-inflammatory function.

Low levels of Uteroglobin have been associated with respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). By affecting inflammation pathways Uteroglobin interacts with inflammatory cytokines which exacerbate these conditions. Additionally its connection to proteins involved in these pathways makes it a potential biomarker for assessing lung injury and monitoring disease progression.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

See full target information Scgb1a1

style

left-column

Publications (54)

Recent publications for all applications. Explore the full list and refine your search

Virology journal 21:302 PubMed39581991

2024

Tropism of adeno-associated virus serotypes in mouse lungs via intratracheal instillation.

Applications

Unspecified application

Species

Unspecified reactive species

Haoyu Wu,Ailing Zhao,Ye Bu,Weiping Yang,Lang He,Yujian Zhong,Dong Yao,Huapeng Li,Wenguang Yin

Respiratory research 25:382 PubMed39427175

2024

MiR-125b-5p alleviates pulmonary fibrosis by inhibiting TGFβ1-mediated epithelial-mesenchymal transition via targeting BAK1.

Applications

Unspecified application

Species

Unspecified reactive species

Shuang Zhou,Wenzhao Cheng,Yifei Liu,Hongzhi Gao,Liying Yu,Yiming Zeng

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2308622 PubMed39360593

2024

The T-Type Calcium Channel CACNA1H is Required for Smooth Muscle Cytoskeletal Organization During Tracheal Tubulogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Ziying Liu,Chunyan Lu,Li Ma,Changjiang Li,Haiyun Luo,Yiqi Liu,Xinyuan Liu,Haiqing Li,Yachao Cui,Jiahang Zeng,Natalia Bottasso-Arias,Debora Sinner,Le Li,Jian Wang,Didier Y R Stainier,Wenguang Yin

Cellular and molecular life sciences : CMLS 81:321 PubMed39078462

2024

Clara cell 10 (CC10) protein attenuates allergic airway inflammation by modulating lung dendritic cell functions.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Dong Xu,Mi Cheng,Jun-Xia Mao,Xue Zhang,Pan-Pan Shang,Jie Long,Yan-Jiao Chen,Yu Wang,Lei-Miao Yin,Yong-Qing Yang

Radiation research 202:552-564 PubMed39048109

2024

Mitigating Viral Impact on the Radiation Response of the Lung.

Applications

Unspecified application

Species

Unspecified reactive species

Angela M Groves,Nicole D Paris,Carl J Johnston,Eric Hernady,Jacob Finkelstein,Paige Lawrence,Brian Marples

Cell reports 43:114286 PubMed38796854

2024

CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Bongjun Kim,Shengzhe Zhang,Yuanjian Huang,Kyung-Pil Ko,Youn-Sang Jung,Jinho Jang,Gengyi Zou,Jie Zhang,Sohee Jun,Kee-Beom Kim,Kwon-Sik Park,Jae-Il Park

Cell death & disease 14:844 PubMed38114479

2023

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Zhangchu Jin,Zhehua Shao,Shiyi Yang,Anyi Guo,Yinling Han,Yinfang Wu,Yun Zhao,Yanping Wu,Jiaxin Shen,Min Zhang,Xueqin Zhan,Wenqi Diao,Songmin Ying,Chao Zhang,Wen Li,Huahao Shen,Zhihua Chen,Fugui Yan

Microbiology spectrum 12:e0246923 PubMed38009950

2023

Spatiotemporal analysis of SARS-CoV-2 infection reveals an expansive wave of monocyte-derived macrophages associated with vascular damage and virus clearance in hamster lungs.

Applications

Unspecified application

Species

Unspecified reactive species

Ola Bagato,Anne Balkema-Buschmann,Daniel Todt,Saskia Weber,André Gömer,Bingqian Qu,Csaba Miskey,Zoltan Ivics,Thomas C Mettenleiter,Stefan Finke,Richard J P Brown,Angele Breithaupt,Dmitry S Ushakov

Cell death & disease 14:324 PubMed37173333

2023

Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Shakti Sagar,Md Imam Faizan,Nisha Chaudhary,Vandana Singh,Praveen Singh,Atish Gheware,Khushboo Sharma,Iqbal Azmi,Vijay Pal Singh,Gaurav Kharya,Ulaganathan Mabalirajan,Anurag Agrawal,Tanveer Ahmad,Soumya Sinha Roy

Journal of virology 97:e0020923 PubMed37120831

2023

Generation of Human Embryonic Stem Cell-Derived Lung Organoids for Modeling Infection and Replication Differences between Human Adenovirus Types 3 and 55 and Evaluating Potential Antiviral Drugs.

Applications

Unspecified application

Species

Unspecified reactive species

Shanshan Zhao,Xiaowei Wu,Zhihong Tan,Yi Ren,Lian Li,Junxian Ou,Ying Lin,Hongbin Song,Liqiang Feng,Donald Seto,Jianguo Wu,Qiwei Zhang,Zhili Rong

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Uteroglobin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uteroglobin antibody (AB40873)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uteroglobin antibody (AB40873)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (54)

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Product promise