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AB244800

Anti-Uteroglobin antibody [EPR21763-43] - BSA and Azide free (Capture)

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Rabbit Recombinant Monoclonal Uteroglobin antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

View Alternative Names

CC10, CCSP, UGB, SCGB1A1, Uteroglobin, Club cell phospholipid-binding protein, Club cells 10 kDa secretory protein, Secretoglobin family 1A member 1, Urinary protein 1, CCPBP, UP-1, UP1, Urine protein 1

1 Images
Sandwich ELISA - Anti-Uteroglobin antibody [EPR21763-43] - BSA and Azide free (Capture) (AB244800)
  • sELISA

Unknown

Sandwich ELISA - Anti-Uteroglobin antibody [EPR21763-43] - BSA and Azide free (Capture) (AB244800)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab238266).

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR21763-43

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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Product details

ab244800 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human Uteroglobin. The recommended pair for sandwich ELISA is:
Capture: ab244800, Human Uteroglobin Capture Antibody (unconjugated)
Detector: ab245073, Human Uteroglobin Detector Antibody (unconjugated)
The reference range value is 6.3 - 400 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Uteroglobin also known as Clara cell secretory protein (CC16) is a small secreted protein with a molecular mass of approximately 16 kDa. Expressed chiefly in the respiratory epithelium of the lungs particularly by Clara cells it is also present in other tissues such as the kidney and uterus. Uteroglobin acts as an anti-inflammatory and immunomodulatory protein playing an important role in protecting epithelial cells from damage by various harmful agents.
Biological function summary

Uteroglobin serves as a multifunctional secretory agent contributing to the regulation of inflammation and tissue remodeling. It does not form part of a larger complex but acts independently. By binding and inhibiting pro-inflammatory mediators like phospholipase A2 Uteroglobin reduces the production of arachidonic acid derivatives which are involved in inflammatory processes. Additionally it acts as a chemoattractant for certain immune cells further modulating immune responses.

Pathways

Uteroglobin integrates into the immune response and inflammation pathways. It indirectly interacts with proteins such as cytokines and chemokines influencing pathways like the arachidonic acid metabolism pathway and the leukocyte extravasation signaling pathway. These interactions reduce inflammatory response and regulate immune cell movement demonstrating its anti-inflammatory function.

Low levels of Uteroglobin have been associated with respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). By affecting inflammation pathways Uteroglobin interacts with inflammatory cytokines which exacerbate these conditions. Additionally its connection to proteins involved in these pathways makes it a potential biomarker for assessing lung injury and monitoring disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
See full target information SCGB1A1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com