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AB235327

Anti-UTP23 antibody

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(1 Publication)

Rabbit Polyclonal UTP23 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human UTP23.

View Alternative Names

C8orf53, UTP23, rRNA-processing protein UTP23 homolog

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UTP23 antibody (AB235327)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UTP23 antibody (AB235327)

Paraffin-embedded human adrenal gland tissue stained for UTP23 using ab235327 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-UTP23 antibody (AB235327)
  • WB

Supplier Data

Western blot - Anti-UTP23 antibody (AB235327)

All lanes:

Western blot - Anti-UTP23 antibody (ab235327) at 1/500 dilution

All lanes:

Mouse liver tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 28 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UTP23 antibody (AB235327)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UTP23 antibody (AB235327)

Paraffin-embedded human liver cancer tissue stained for UTP23 using ab235327 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human UTP23.

Q9BRU9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UTP23 also known as suppressor of los1 homolog 1 (SUSH1) is a protein involved in ribosome biogenesis specifically in the processing of small nucleolar ribonucleoproteins. The protein has a molecular mass of approximately 26 kDa. UTP23 is expressed mainly in the nucleolus of cells where ribosome assembly occurs. Its function involves participation in the cleavage of pre-rRNA necessary for the maturation of 18S rRNA which is an essential component of the small ribosomal subunit.
Biological function summary

UTP23 participates in the formation of the small subunit (SSU) processome a large ribonucleoprotein complex essential for early stages of pre-rRNA processing. This complex plays an important role in the biogenesis of the 40S ribosomal subunit. The function of UTP23 in this complex ensures proper ribosome assembly impacting protein synthesis rates within the cell. The presence of UTP23 in the SSU processome highlights its importance in maintaining ribosome function integrity.

Pathways

UTP23 is integral within the ribosome biogenesis pathway linking it to the synthesis and assembly of ribosomes. It interacts with proteins such as UTP4 and UTP18 which also contribute to pre-rRNA processing and ribosomal assembly. The correct functioning of these pathways is important for the production of functional ribosomes which impacts overall gene expression and cellular productivity.

Defects in UTP23 activity have associations with disorders such as Diamond-Blackfan anemia and Treacher Collins syndrome. Both conditions often involve disruptions in ribosomal biogenesis. UTP23's connection to proteins like ribosomal protein S19 (RPS19) in these disorders highlights its significance. These disorders highlight the importance of accurate function and regulation of UTP23 for maintaining normal cellular activity and preventing disease states.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in rRNA-processing and ribosome biogenesis.
See full target information UTP23
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:107446 PubMed37599822

2023

Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1.

Applications

Unspecified application

Species

Unspecified reactive species

Lingxiao Tong,Jia Rao,Chenxi Yang,Jie Xu,Yijun Lu,Yuchen Zhang,Xiaohui Cang,Shanshan Xie,Jianhua Mao,Pingping Jiang
View all publications
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