JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB60063

Anti-UTP3 antibody [2950C2a]

0

(1 Review)

|

(2 Publications)

Mouse Monoclonal UTP3 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human UTP3.

View Alternative Names

CRLZ1, SAS10, UTP3, Something about silencing protein 10, Charged amino acid-rich leucine zipper 1, Disrupter of silencing SAS10, UTP3 homolog, CRL1

1 Images
Western blot - Anti-UTP3 antibody [2950C2a] (AB60063)
  • WB

Unknown

Western blot - Anti-UTP3 antibody [2950C2a] (AB60063)

The molecular weight of the band on the western blot does not correspond to the molecular weight of the natural protein because only a fragment of the protein was used.

All lanes:

Western blot - Anti-UTP3 antibody [2950C2a] (ab60063)

All lanes:

immunising recombinant protein

Predicted band size: 55 kDa

Observed band size: 39 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2950C2a

Isotype

IgG1

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human UTP3. The exact immunogen used to generate this antibody is proprietary information.

Q9NQZ2

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
ab60063 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.1136% Disodium hydrogenorthophosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UTP3 also known as Utp3p is a component of the small subunit processome involved in ribosome biogenesis. This protein has a mass of approximately 65 kDa and mainly localizes in the nucleolus of eukaryotic cells. UTP3 plays an important role in the early steps of 18S rRNA processing as part of the preribosomal particle assembly. This early involvement is essential for the production of the small ribosomal subunit which impacts protein synthesis.
Biological function summary

UTP3 engages in ribosome assembly interacting with other proteins within the small subunit (SSU) processome complex. This complex processes pre-rRNA into mature rRNA critical for ribosome function. UTP3's role ensures the accuracy and efficiency of rRNA folding and processing which is essential for the assembly of functional ribosomal units in eukaryotic cells.

Pathways

UTP3 is highly involved in the ribosome biogenesis pathway. This pathway is critical for cell growth and proliferation as it directly affects translation and protein synthesis. UTP3 associates with other SSU processome proteins like UTP4 and UTP15 facilitating pre-rRNA processing and ribosome assembly. These interactions highlight UTP3's importance in maintaining the integrity of the protein synthesis machinery.

Abnormalities in UTP3 function can relate to ribosomopathies and cancer. Disruptions in ribosome biogenesis involving proteins like UTP3 can lead to improper cell growth and proliferation often noted in cancers. Additionally any aberration in its interaction with other nucleolar proteins like UTP4 may further impact disease manifestation reflecting UTP3's significance in maintaining cellular homeostasis.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Essential for gene silencing : has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797).
See full target information UTP3
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology (Baltimore, Md. : 1950) 203:2630-2643 PubMed31586036

2019

Controls Germinal Center Reaction by Relaying a Wnt Signal to the Expression in Centroblasts during Humoral Immune Responses.

Applications

Unspecified application

Species

Unspecified reactive species

Seung Young Choi,Joo Hyun Pi,Sung-Kyun Park,Chang Joong Kang

Stem cell reports 11:756-769 PubMed30174317

2018

The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Terrigno,Michele Bertacchi,Luca Pandolfini,Mario Baumgart,Mariantonietta Calvello,Alessandro Cellerino,Michèle Studer,Federico Cremisi
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB252975

Anti-CYP2U1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2U1 antibody (AB252975)

  • 0
  • 0
Primary Antibodies

AB103167

Anti-Inhibin beta E chain antibody

Western blot - Anti-Inhibin beta E chain antibody (AB103167)

  • 0
  • 0
Primary Antibodies

AB254715

Anti-ZNF503 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

  • 0
  • 0
Primary Antibodies

AB252955

Anti-UROS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UROS antibody (AB252955)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com