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AB244363

Anti-Utrophin antibody

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(1 Publication)

Rabbit Polyclonal Utrophin antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UTRN aa 1350-1500.

View Alternative Names

DMDL, DRP1, UTRN, Utrophin, Dystrophin-related protein 1, DRP-1

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Utrophin with ab244363 at a 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Formalin-fixed, paraffin-embedded human stomach tissue stained for Utrophin with ab244363 at a 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Formalin-fixed, paraffin-embedded human prostate tissue stained for Utrophin with ab244363 at a 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Formalin-fixed, paraffin-embedded human liver tissue stained for Utrophin with ab244363 at a 1/50 dilution in immunohistochemical analysis.

No membranous positivity in hepatocytes as expected.

Immunocytochemistry/ Immunofluorescence - Anti-Utrophin antibody (AB244363)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Utrophin antibody (AB244363)

PFA fixed, Triton X-100 permeabilized U-251 MG (Human brain glioma cell line) cells labeling Utrophin using ab244363 at 4 μg/ml (green) in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human UTRN aa 1350-1500. The exact immunogen used to generate this antibody is proprietary information.

P46939

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Utrophin also known as dystrophin-related protein plays a mechanical role in muscle tissue by connecting the cytoskeleton to the extracellular matrix. It has a molecular mass of about 395 kDa. This protein localizes mainly at the neuromuscular junctions and myotendinous junctions. Utrophin shows expression in various tissues but is more common in fetal and regenerating muscle fibers suggesting its function is important during muscle development and repair.
Biological function summary

Utrophin maintains muscle integrity and stability by forming part of the dystrophin-associated glycoprotein complex. This complex acts as a scaffold needed for structural support in muscle cells aiding in proper muscle function and repair. Utrophin substitutes dystrophin especially when dystrophin is absent or defective in muscles making it an important player in compensatory mechanisms.

Pathways

Utrophin actively participates in muscle signaling and structural integrity processes. It is important within the Jak-STAT signaling pathway and the pathways involved in muscle dystrophy. Through these pathways utrophin interacts with proteins like dystroglycans and sarcoglycans which help support its role in maintaining the structural framework of muscle tissues.

The absence or abnormal expression of utrophin is linked to muscular dystrophies especially Duchenne Muscular Dystrophy (DMD). Utrophin is being explored as a potential therapeutic target to compensate for the lack of dystrophin in this context. Enhanced expression of utrophin may alleviate muscle degeneration seen in DMD by interacting with proteins normally associated with dystrophin in healthy muscle like syntrophins and sarcospan.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in anchoring the cytoskeleton to the plasma membrane.
See full target information UTRN
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 31:278 PubMed40819077

2025

Targeting LINC02544/miR-497-5p/CAPRIN1 axis via exosome-based siRNA to overcome immunotherapy resistance in triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Lian,Jiayi Li,Shihui Tang,Ting Li,Jinping Li
View all publications
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Product promise

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