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AB155226

Anti-UXS-1 antibody

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(1 Publication)

Rabbit Polyclonal UXS-1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UXS1 aa 150-400.

View Alternative Names

UNQ2538/PRO6079, UXS1, UDP-glucuronic acid decarboxylase 1, UDP-glucuronate decarboxylase 1, UGD, UXS-1, hUXS, hUXS1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UXS-1 antibody (AB155226)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UXS-1 antibody (AB155226)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue, labeling UXS-1 using ab155226 at a 1/500 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human UXS1 aa 150-400. The exact immunogen used to generate this antibody is proprietary information.

Q8NBZ7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Antigen retrieval also possible using Tris-EDTA buffer (pH8.0).</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus tropicalis": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Zebrafish": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UDP-xylose synthase 1 also known as UXS-1 plays a role in converting UDP-glucuronic acid to UDP-xylose. This enzyme has a molecular mass of approximately 53 kDa. It is expressed in a variety of tissues but most notably in plant cells where it contributes to cell wall biosynthesis. Alternate names for UXS-1 include UDP-glucuronate decarboxylase. UXS-1 directs the synthesis of nucleotide sugar substrates necessary for glycosylation processes.
Biological function summary

UDP-xylose synthase 1 is important for the biosynthesis of glycosaminoglycans and proteoglycans which are vital structural components in plant cells. UXS-1 participates in the early steps of polysaccharide assembly essential for plant cell wall formation. This enzyme operates often as part of a larger complex that ensures the proper supply of xylose for emergent cellular needs. Through its enzymatic activity it facilitates important steps in the cell's utilization of carbohydrate substrates.

Pathways

UXS-1 is integral to the xylose biosynthetic pathway. This pathway influences the production of hemicellulose an important element of plant cell walls. In this context UXS-1 acts alongside other enzymes such as UDP-glucuronic acid decarboxylases to ensure proper polysaccharide formation. The protein colocalizes with enzymes like UDP-glucose dehydrogenase within the same biosynthetic pathways forming a tight network of carbohydrate metabolism.

Disturbances in the activity of UXS-1 may link to certain plant growth deficiencies. Variations in the regulation of UXS-1 can cause developmental disorders tied to defective cell wall formation and function. UXS-1's interaction with the processes governed by UDP-glucose dehydrogenase highlights potential dysregulation scenarios albeit such associations are often explored within the confines of plant biology rather than human disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed : 22810237, PubMed : 23656592, PubMed : 25521717, PubMed : 40836090). Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed : 22810237, PubMed : 23656592, PubMed : 25521717, PubMed : 40836090). Catalyzes the synthesis of UDP-xylose in two steps : the hydroxyl group of UDP-glucuronic acid is first oxidized using an enzyme-bound NAD(+) as electron acceptor, favoring the decarboxylation yielding a UDP-4-ketoxylose reaction intermediate and a reduced cofactor NADH bound to the catalytic pocket (PubMed : 22810237, PubMed : 40836090). In the second step, the 4-keto group is reduced resulting in UDP-xylose and the restoration of the enzyme to its NAD(+)-bound form (PubMed : 22810237, PubMed : 40836090).
See full target information UXS1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular neurobiology 43:1199-1218 PubMed35748966

2022

LncRNA Pnky Positively Regulates Neural Stem Cell Migration by Modulating mRNA Splicing and Export of Target Genes.

Applications

Unspecified application

Species

Unspecified reactive species

Jiannan Du,Yuan Li,Yuting Su,Wenqian Zhi,Jiale Zhang,Cheng Zhang,Juan Wang,Wensheng Deng,Shasha Zhao
View all publications
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Product promise

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