Rabbit Polyclonal UXS-1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human UXS1 aa 150-400.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human UXS1 aa 150-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NBZ7
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
| Cow | Predicted | Predicted |
| Xenopus tropicalis | Predicted | Predicted |
| Zebrafish | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes Antigen retrieval also possible using Tris-EDTA buffer (pH8.0). Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow, Zebrafish, Xenopus tropicalis | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow, Zebrafish, Xenopus tropicalis | Dilution info - | Notes - |
Target data
Function
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:22810237, PubMed:23656592, PubMed:25521717). Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:22810237, PubMed:23656592, PubMed:25521717).
Alternative names
UNQ2538/PRO6079, UXS1, UDP-glucuronic acid decarboxylase 1, UDP-glucuronate decarboxylase 1, UGD, UXS-1, hUXS, hUXS1
Recommended products
Rabbit Polyclonal UXS-1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human UXS1 aa 150-400.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human UXS1 aa 150-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NBZ7
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
UDP-xylose synthase 1 also known as UXS-1 plays a role in converting UDP-glucuronic acid to UDP-xylose. This enzyme has a molecular mass of approximately 53 kDa. It is expressed in a variety of tissues but most notably in plant cells where it contributes to cell wall biosynthesis. Alternate names for UXS-1 include UDP-glucuronate decarboxylase. UXS-1 directs the synthesis of nucleotide sugar substrates necessary for glycosylation processes.
- Biological function summary
UDP-xylose synthase 1 is important for the biosynthesis of glycosaminoglycans and proteoglycans which are vital structural components in plant cells. UXS-1 participates in the early steps of polysaccharide assembly essential for plant cell wall formation. This enzyme operates often as part of a larger complex that ensures the proper supply of xylose for emergent cellular needs. Through its enzymatic activity it facilitates important steps in the cell's utilization of carbohydrate substrates.
- Pathways
UXS-1 is integral to the xylose biosynthetic pathway. This pathway influences the production of hemicellulose an important element of plant cell walls. In this context UXS-1 acts alongside other enzymes such as UDP-glucuronic acid decarboxylases to ensure proper polysaccharide formation. The protein colocalizes with enzymes like UDP-glucose dehydrogenase within the same biosynthetic pathways forming a tight network of carbohydrate metabolism.
- Associated diseases and disorders
Disturbances in the activity of UXS-1 may link to certain plant growth deficiencies. Variations in the regulation of UXS-1 can cause developmental disorders tied to defective cell wall formation and function. UXS-1's interaction with the processes governed by UDP-glucose dehydrogenase highlights potential dysregulation scenarios albeit such associations are often explored within the confines of plant biology rather than human disease contexts.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-UXS-1 antibody (ab155226)
All lanes: Western blot - Anti-UXS-1 antibody (ab155226) at 1/1000 dilution
Lane 1: Jurkat at 30 µg
Lane 2: Raji at 30 µg
Predicted band size: 48 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UXS-1 antibody (ab155226)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue, labeling UXS-1 using ab155226 at a 1/500 dilution.
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