Anti-UXT antibody

Target data

Involved in gene transcription regulation (PubMed : 21730289, PubMed : 28106301). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed : 11854421, PubMed : 21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed : 21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed : 28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed : 17620405, PubMed : 21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed : 17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed : 17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed : 17635584).. Isoform 1. Plays a role in protecting cells against TNF-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.