AB3347

Anti-VAMP2 antibody

4

(3 Reviews)

|

(53 Publications)

Rabbit Polyclonal VAMP2 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 53 publications. Immunogen corresponding to Synthetic Peptide within Rat Vamp2 aa 1-50.

View Alternative Names

Syb2, Vamp2, Vesicle-associated membrane protein 2, VAMP-2, Synaptobrevin-2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB

Immunogen

Synthetic Peptide within Rat Vamp2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

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Alternative Products

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Constituents: PBS, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Vesicle-associated membrane protein 2 (VAMP2) also known as synaptobrevin 2 is a member of the SNARE protein family with a molecular mass of approximately 13 kDa. VAMP2 plays an important role in vesicle trafficking and membrane fusion particularly in the nervous system. It is prominently expressed in the brain where it facilitates neurotransmitter release by forming SNARE complexes essential for synaptic vesicle fusion with the presynaptic membrane.

Biological function summary

VAMP2 interacts with other SNARE proteins such as synaptosomal-associated protein 25 (SNAP-25) and syntaxin-1 to form stable complexes necessary for synaptic vesicle docking and exocytosis. As part of the SNARE complex VAMP2 contributes to the precise regulation of neurotransmitter release in neurons which is critical for synaptic transmission and plasticity. Its function is vital for the communication between neurons and proper brain function.

Pathways

VAMP2 plays a significant role in the synaptic vesicle cycle and neurotransmitter release pathways. It is central to the exocytosis pathway where it interacts with Rab3a a small GTPase that regulates vesicle docking. By participating in these pathways VAMP2 ensures efficient neurotransmission and contributes to neuronal communication processes. VAMP2's interaction with related proteins like SNAP-25 and syntaxin-1 highlights its importance in these synaptic processes.

VAMP2 has associations with conditions such as epilepsy and neurodegenerative diseases. Alterations in VAMP2 expression or function can disrupt normal neurotransmitter release impacting synaptic function and leading to neurological symptoms. VAMP2's relationship with SNAP-25 and syntaxin-1 further implicates it in these disorders as these proteins collectively regulate neural communication. Understanding VAMP2's role in these illnesses aids in the development of potential therapeutic strategies targeting SNARE complex dysfunctions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (Probable). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed : 19690160).

See full target information Vamp2

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Publications (53)

Recent publications for all applications. Explore the full list and refine your search

NPJ Parkinson's disease 11:242 PubMed40804075

2025

Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Lluis Miquel-Rio,Judith Jericó-Escolar,Unai Sarriés-Serrano,Claudia Yanes-Castilla,María Torres-López,Uxia Argibay,Verónica Paz,Carme Casal,Emma Muñoz-Moreno,Xavier López-Gil,Analia Bortolozzi

Molecular autism 15:28 PubMed38877552

2024

Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Simões de Oliveira,Heather E O'Leary,Sarfaraz Nawaz,Rita Loureiro,Elizabeth C Davenport,Paul Baxter,Susana R Louros,Owen Dando,Emma Perkins,Julien Peltier,Matthias Trost,Emily K Osterweil,Giles E Hardingham,Michael A Cousin,Sumantra Chattarji,Sam A Booker,Tim A Benke,David J A Wyllie,Peter C Kind

iScience 26:108050 PubMed37876798

2023

Pre- and postsynaptic N-methyl-D-aspartate receptors are required for sequential printing of fear memory engrams.

Applications

Unspecified application

Species

Unspecified reactive species

Ilaria Bertocchi,Florbela Rocha-Almeida,María Teresa Romero-Barragán,Marco Cambiaghi,Alejandro Carretero-Guillén,Paolo Botta,Godwin K Dogbevia,Mario Treviño,Paolo Mele,Alessandra Oberto,Matthew E Larkum,Agnes Gruart,Rolf Sprengel,José Maria Delgado-García,Mazahir T Hasan

Nature communications 14:5718 PubMed37714837

2023

CN nanodots inhibits Aβ peptides aggregation pathogenic path in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xiuhua Yin,Hong Zhou,Mengling Zhang,Juan Su,Xiao Wang,Sijie Li,Zaixing Yang,Zhenhui Kang,Ruhong Zhou

Communications biology 6:422 PubMed37061616

2023

Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Lorraine Madur,Christian Ineichen,Giorgio Bergamini,Alexandra Greter,Giulia Poggi,Nagiua Cuomo-Haymour,Hannes Sigrist,Yaroslav Sych,Jean-Charles Paterna,Klaus D Bornemann,Coralie Viollet,Francesc Fernandez-Albert,Gregorio Alanis-Lobato,Bastian Hengerer,Christopher R Pryce

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e22734 PubMed36583697

2022

ADAM10- and γ-secretase-dependent cleavage of the transmembrane protein PTPRT attenuates neurodegeneration in the mouse model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Siling Liu,Zhongyu Zhang,Lianwei Li,Li Yao,Zhanshan Ma,Jiali Li

Molecular therapy : the journal of the American Society of Gene Therapy 30:2163-2175 PubMed35283272

2022

Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Zongyang Lu,Siting He,Jian Jiang,Ling Zhuang,Yan Wang,Guang Yang,Xiaoyu Jiang,Yanhong Nie,Jiqiang Fu,Xiaotong Zhang,Yong Lu,Xinyan Bian,Hung-Chun Chang,Zhiqi Xiong,Xingxu Huang,Zhen Liu,Qiang Sun

Science advances 7: PubMed33931449

2021

Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.

Applications

Unspecified application

Species

Unspecified reactive species

Daniela Ivanova,Katharine L Dobson,Akshada Gajbhiye,Elizabeth C Davenport,Daniela Hacker,Sila K Ultanir,Matthias Trost,Michael A Cousin

Cell reports 34:108842 PubMed33730593

2021

Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Chen,Ying-Han Wang,Yi Zheng,Meijing Li,Bing Wang,Qiu-Wen Wang,Chong-Lei Fu,Yao-Nan Liu,Xueming Li,Jun Yao

Molecular metabolism 45:101151 PubMed33359402

2020

The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ilka Wilhelmi,Stephan Grunwald,Niclas Gimber,Oliver Popp,Gunnar Dittmar,Anup Arumughan,Erich E Wanker,Thomas Laeger,Jan Schmoranzer,Oliver Daumke,Annette Schürmann

View all publications

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