Anti-VAMP5 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Vesicle fusion and neurotransmission heavily depend on VAMP5 as it forms part of the SNARE complex. It binds with other SNARE proteins such as SNAP25 and syntaxin to facilitate the docking and fusion of vesicles at the plasma membrane. The correct function of VAMP5 ensures proper communication between cells helping regulate muscle contraction and relaxation. VAMP5's role in muscular tissues emphasizes its importance in maintaining normal physiological processes in these tissues and organs.

Pathways

VAMP5 operates within the exocytosis pathway and is central to synaptic vesicle fusion. It works in concert with other proteins of the SNARE complex to mediate vesicle targeting to the membrane important for neurotransmitter release at synaptic junctions. Additionally it interacts with synaptotagmins which act as sensors for calcium ions further ensuring precise timing and regulation of vesicle fusion during neurotransmission. These interactions illustrate the integration of VAMP5 in critical pathways responsible for neural and muscular functions.