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AB81718

Anti-VAP1 antibody [174-5]

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(2 Publications)

Mouse Monoclonal VAP1 antibody. Suitable for IHC-Fr and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Tissue preparation containing AOC3 protein.

View Alternative Names

VAP1, AOC3, Amine oxidase [copper-containing] 3, Amine oxidase copper-containing 3, Copper amine oxidase, HPAO, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1, SSAO, VAP-1

1 Images
Immunohistochemistry (Frozen sections) - Anti-VAP1 antibody [174-5] (AB81718)
  • IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-VAP1 antibody [174-5] (AB81718)

ab81718 at 1/50 dilution staining VAP1 in human tonsil tissue section by Immunohistochemistry (frozen sections).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

174-5

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-Fr

applications

Immunogen

Tissue preparation containing AOC3 protein. The exact immunogen used to generate this antibody is proprietary information.

Q16853

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/50", "IHCFr-species-notes": "<p></p>" } } }
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Product details

This antibody inhibits lymphocyte infiltration in liver allograft rejection in rats.
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Properties and storage information

Form
Liquid
Purification notes
ab81718 is purified and 0.2µM filtered.
Storage buffer
Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Vascular Adhesion Protein 1 (VAP1) also known as amine oxidase copper-containing 3 (AOC3) has a mechanical function involving its enzyme activity to catalyze oxidative deamination of primary amines to produce aldehydes hydrogen peroxide and ammonia. The protein has an approximate mass of 90 kDa. VAP1 is expressed on the surface of endothelial cells and some smooth muscle cells especially in tissues like liver lung and gut. It functions mainly in cellular adhesion processes.
Biological function summary

VAP1 plays important roles in leukocyte trafficking what makes it important for immune response and inflammation. It facilitates the adhesion and transmigration of leukocytes across the endothelium into tissues. VAP1 is part of numerous adhesion molecule networks that help regulate the immune response. Its ability to interact with diverse substrates also affects vascular function and integrity.

Pathways

VAP1 interacts with immune responses and inflammation-related pathways. It influences the leukocyte adhesion cascade which integrates with the immune cell signaling pathways. Proteins like Integrins and Selectins relate to VAP1 in these processes as they are also involved in mediating cell adhesion to the endothelial cells thereby orchestrating cell movement and positioning essential for immune defense.

VAP1 has been implicated in chronic inflammatory diseases and certain cancers. Inflammatory bowel disease is one condition where VAP1's role in leukocyte trafficking results in sustained inflammation. Additionally its elevated expression in some tumors links it to cancer progression via promoting tumor-associated inflammation. The connection between VAP1 and proteins like TNF-alpha becomes clearer in the inflammation context serving as a potential therapeutic target for modulating inflammatory and cancerous conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed : 19588076, PubMed : 24304424, PubMed : 9653080). Has a preference for the primary monoamines methylamine and benzylamine (PubMed : 19588076, PubMed : 9653080). Could also act on 2-phenylethylamine but much less efficiently (PubMed : 19588076). At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion (PubMed : 9254657, PubMed : 9653080).. Isoform 2. Has no semicarbazide-sensitive amine oxidase (SSAO) activity.
See full target information AOC3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 16:1189-1199 PubMed28627649

2017

Hypoxia serves a key function in the upregulated expression of vascular adhesion protein‑1 in vitro and in a rat model of hemorrhagic shock.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxing Zhang,Wei Yi,Jun Yao,Xiaojun Yu,Cheng Qian,Zhiqian Hu

The American journal of pathology 165:1993-2001 PubMed15579442

2004

Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection.

Applications

Unspecified application

Species

Unspecified reactive species

Timi Martelius,Ville Salaspuro,Marko Salmi,Leena Krogerus,Krister Höckerstedt,Sirpa Jalkanen,Irmeli Lautenschlager
View all publications
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