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AB187202

Anti-VAP1 antibody

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(2 Publications)

Rabbit Polyclonal VAP1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AOC3 aa 1-200.

View Alternative Names

VAP1, AOC3, Amine oxidase [copper-containing] 3, Amine oxidase copper-containing 3, Copper amine oxidase, HPAO, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1, SSAO, VAP-1

1 Images
Western blot - Anti-VAP1 antibody (AB187202)
  • WB

Supplier Data

Western blot - Anti-VAP1 antibody (AB187202)

All lanes:

Western blot - Anti-VAP1 antibody (ab187202) at 1/500 dilution

Lane 1:

Mouse kidney tissue extract

Lane 2:

Mouse liver tissue extract

Lane 3:

Mouse heart tissue extract

Predicted band size: 85 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human AOC3 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q16853

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Vascular Adhesion Protein 1 (VAP1) also known as amine oxidase copper-containing 3 (AOC3) has a mechanical function involving its enzyme activity to catalyze oxidative deamination of primary amines to produce aldehydes hydrogen peroxide and ammonia. The protein has an approximate mass of 90 kDa. VAP1 is expressed on the surface of endothelial cells and some smooth muscle cells especially in tissues like liver lung and gut. It functions mainly in cellular adhesion processes.
Biological function summary

VAP1 plays important roles in leukocyte trafficking what makes it important for immune response and inflammation. It facilitates the adhesion and transmigration of leukocytes across the endothelium into tissues. VAP1 is part of numerous adhesion molecule networks that help regulate the immune response. Its ability to interact with diverse substrates also affects vascular function and integrity.

Pathways

VAP1 interacts with immune responses and inflammation-related pathways. It influences the leukocyte adhesion cascade which integrates with the immune cell signaling pathways. Proteins like Integrins and Selectins relate to VAP1 in these processes as they are also involved in mediating cell adhesion to the endothelial cells thereby orchestrating cell movement and positioning essential for immune defense.

VAP1 has been implicated in chronic inflammatory diseases and certain cancers. Inflammatory bowel disease is one condition where VAP1's role in leukocyte trafficking results in sustained inflammation. Additionally its elevated expression in some tumors links it to cancer progression via promoting tumor-associated inflammation. The connection between VAP1 and proteins like TNF-alpha becomes clearer in the inflammation context serving as a potential therapeutic target for modulating inflammatory and cancerous conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed : 19588076, PubMed : 24304424, PubMed : 9653080). Has a preference for the primary monoamines methylamine and benzylamine (PubMed : 19588076, PubMed : 9653080). Could also act on 2-phenylethylamine but much less efficiently (PubMed : 19588076). At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion (PubMed : 9254657, PubMed : 9653080).. Isoform 2. Has no semicarbazide-sensitive amine oxidase (SSAO) activity.
See full target information AOC3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cardiovascular medicine 8:792180 PubMed34970611

2021

A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Prasanta K Dash,Fadhel A Alomar,Jesse L Cox,JoEllyn McMillan,Bryan T Hackfort,Edward Makarov,Brenda Morsey,Howard S Fox,Howard E Gendelman,Santhi Gorantla,Keshore R Bidasee

Molecular medicine reports 16:1189-1199 PubMed28627649

2017

Hypoxia serves a key function in the upregulated expression of vascular adhesion protein‑1 in vitro and in a rat model of hemorrhagic shock.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxing Zhang,Wei Yi,Jun Yao,Xiaojun Yu,Cheng Qian,Zhiqian Hu
View all publications
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